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VBTPD employees are active members of leading international and national memberships in international professional organizations (European Society for Medical Oncology ESMO; European Association for the Study of Cancer EACR; European Cancer Organization ECCO; European Society for Medical Oncology ESMO; European Association for the Study of Cancer EACR; International Association against cancer Ukrainian society of geneticists O.M. Perepelitsyn, reviewer of journal "Targeted Oncology".
VBTPD has established fruitful relations with such organizations of the National Academy of Sciences of Ukraine as the Institute of Surface Chemistry named after O.O. Chuyka, Institute of Metallophysics, Institute of Physics, SKTB "Institute of Cryobiology and Cryomedicine", National Cancer Institute (MoH of Ukraine), Ukrainian Medical and Stomatological Academy; NSC "Institute of Biology" of Kyiv National University named after Taras Shevchenko, National Institute of Applied Sciences of Lyon (France), which allowed not only to present the results of research in joint publications, but also to prepare applications for participation in international programs.
Young scientists of the State University "Department of Biotechnical Problems of Diagnostics of the Institute of Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine" undergo training of highly qualified scientific personnel at KNU named after T. Shevchenko through postgraduate studies at the expense of budget funding:
- M.Sc. Gergelyuk T.S. by the decision of the admissions committee and the rector's order No. 606-34 dated 09/28/2016 of Taras Shevchenko National University of Kyiv, he was enrolled as a graduate student of the Educational and Scientific Center "Institute of Biology" with a break from production in the specialty 091 — biology.
Nesterenko O.M. by the decision of the admissions committee and the rector's order No. 820-34 dated 23.11.2015 of Taras Shevchenko National University of Kyiv, he was enrolled as a postgraduate student of the Educational and Scientific Center "Institute of Biology" without a break from production in the specialty 03.00.04 — biochemistry.
DU VBTPD IPKK NAS of Ukraine is the executor of the joint project with KNU named after Taras Shevchenko of the scientific work of young scientists working (studying) in higher educational institutions and scientific institutions belonging to the sphere of management of the Ministry of Education and Culture and carried out at the expense of the funds of the general fund of the state budget, according to the topic (section): Development and implementation of new technologies and equipment for high-quality medical care, pharmaceuticals, disease prevention and treatment; biotechnology; project No. 95503 "Biocompatible water-soluble C60 fullerenes as antifibrotic and antineoplastic agents in malignant neoplasms". Order of the Ministry of Education and Culture of Ukraine No. 983 of July 3, 2017. on the announcement of the competitive selection in 2017 of projects of scientific works and scientific and technical (experimental) developments of young scientists.
Young scientists of the State University "Department of Biotechnical Problems of Diagnostics of the Institute of Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine" undergo training of highly qualified scientific personnel at KNU named after T. Shevchenko through postgraduate studies at the expense of budget funding.
As part of the dissertation work, articles were published in specialized scientific journals with a high impact factor:
1. Perepelitsina O.M., Yastrebova O.V., Yakymchuk O.M., Bezugliy S.V., Yurchenko N.P., Sydorenko M.V., Ostapchenko L.I. The effect of the cytosol of mesenchymal stem cells on the biochemical indicators of the blood of mice and the development of Ehrlich's adenocarcinoma // Buk. Med. Herald. - 2016. - Vol. 20, No. 4 (80). - P. 139-146.
2. Herheliuk T., Perepelytsina O., Sydorenko M., Yurchenko N., Ostapchenko L. Expression of tumor associated and epithelial-mesenchymal transition markers in 2D and 3D cell cultures of MCF-7 // EUREKA: Health Sciences. - 2016. - No. 6. - R. 37-44. DOI: 10.21303/2504-5679. 2016.00231.
3. Herheliuk T., Perepelytsina O., Yakymchuk O., Ostapchenko L., Sydorenko M. 41PThe in vitro and in vivo effects of mesenchymal stem cells on breast cancer cells // Annals of Oncology 28(suppl_1)·May 2017. DOI : 10.1093/annonc/mdx140.003.
4. Herheliuk T., Perepelytsina O., Ostapchenko L., Yakymchuk O., Sydorenko M. Comparison of biological properties of C-medium from mesenchymal stem cells on 2D and 3D cells cultures of MCF-7 // Collection of theses of the XII International Scientific conference of students and postgraduates "Youth and the progress of biology" - Lviv, April 25-27, 2017, Ukraine. - p. 243.
5. Ugnivenko A.P., Perepelitsina O.M., Sydorenko M.V., Ostapchenko L.I. Carbon nanotubes in delivery of bioactive substances // J. Bionanoscience. - 2017. - Vol. 11, No. 6 (17). - P. 531-547. doi.org/10.1166/jbns.2017.1475
In cooperation with scientists from the Faculty of Physics of the National University named after T.G. Shevchenko during the implementation of the National Research Development Program 0112U0055549 "Investigation of the effect of metal-containing and carbon nanomaterials as a pro-differentiation matrix during in vitro cell growth" within the framework of the target program: "Fundamental problems of nanostructured systems, nanomaterials, nanotechnologies" it was found that the nanoscale structure of carbon aggregates of onions, UDA, NT and C60 fullerenes contribute to the reduction
adhesion of cells to the substrate and affects the formation of multicellular aggregates. The correlation between the concentration of BNM and the size of cell spheroids is also confirmed by statistical calculations of the Pearson correlation coefficient. In addition, BNMs have different effects on absorption qualities, affecting the concentration of growth factors in the culture medium and, as a result, on the growth of the tumor culture. The research results are published in the international collection of scientific articles:
1. Perepelytsina O.M., Rud A.D., Gergeliuk T.S., Biliy M.M., Sydorenko M.V., Kiryan I.M. Biochemical and cytotoxic properties of ultra dispersed diamonds // Collection of Scientific Articles "Carbon Particles in Condensed Media" of the VII International Conference "Fullerenes and Nanostructures in Condensed Media", Minsk, Belarus, June 9-12, 2013 - Page 334-339.
In cooperation with scientists from the Faculty of Chemistry of the National University named after T. Shevchenko during the implementation of the National Research Development Program 0112U0055549 "Investigation of the influence of metal-containing and carbon nanomaterials as a pro-differentiation matrix during in vitro cell cultivation" within the framework of the target program: "Fundamental problems of nanostructured systems, nanomaterials, nanotechnologies" the specifics of the influence of nanostructured materials on tumor cell culture models were determined in depending on the physical and chemical parameters of carbon aggregates. The research results were published in an international journal with a high impact factor:
1. Perepelytsina O.M., Sydorenko M.V., Yakymchuk O.M., Dobrydnev A.V. Effect of single-walled carbon nanotubes on tumor cell viability and formation of multicellular tumor spheroids. Nanoscale Research Letters 10(1):150, 2015. DOI: 10.1186/s11671-015-0858-7. IF = 2.833.
In cooperation with the Institute of Metallophysics named after H.V. Kurdyumov of the National Academy of Sciences of Ukraine:
The scientific staff of the VBTPD IPCC of the National Academy of Sciences of Ukraine were involved in the implementation of the scientific project "Investigation of the effect of metal-containing and carbon nanomaterials as a pro-differentiation matrix during cell growth in vitro" of the targeted comprehensive program of fundamental research "Fundamental problems of nanostructured systems, nanomaterials, nanotechnologies" of the National Academy of Sciences of Ukraine for 2010-2014 yr. in terms of performance of works/tasks. The scientific leader of the project from the Department of VBTPD of the National Academy of Sciences of Ukraine is Doctor of Medicine. Sydorenko M.V. (detailed information in section 3.1. National and international scientific communities). Research results are presented in leading scientific journals with a high impact factor:
1. Yakymchuk O.M., Perepelitsina O.M., Rudy O.D., Kiryan I.M., Sydorenko M.V. Study of the influence of the microstructure of nanomaterials on the formation of multicellular spheroids by tumor cells // Nanosystems, nanomaterials, nanotechnologies. - 2013. - V. 11(4). - P. 757-768.
2. Perepelytsina O.M., Rud A.D., Gergeliuk T.S., Biliy M.M., Sydorenko M.V., Kiryan I.M. Biochemical and cytotoxic properties of ultra dispersed diamonds // Collection of Scientific Articles "Carbon Particles in Condensed Media" of the VII International Conference "Fullerenes and Nanostructures in Condensed Media", Minsk, Belarus, June 9-12, 2013 - Page. 334-339.
3. Yakymchuk O.M., Perepelytsina O.M., Rud A.D., Kirian I.M., Sydorenko M.V. Impact of carbon nanomaterials on the formation of multicellular spheroids by tumor cells // Physica status solidi. - 2014. - P. 1-7 / DOI10.1002/psssa.201431358. IF = 1.775.
In cooperation with the Institute of Surface Chemistry named after O.O. Rumor:
the topic of scientific research works "Testing of a carbon-protein construct for the targeted delivery of anticancer drugs" of the target complex interdisciplinary scientific research program of the National Academy of Sciences of Ukraine "Molecular and cellular biotechnologies for the needs of medicine, industry and agriculture" is being carried out. Scientific supervisor — Doctor of Medicine. Sydorenko M.V. The results of joint research are presented in an international journal with a high impact factor:
1. Perepelytsina O.M., Yakymchuk O.M., Sydorenko M.V., Bakalinska O.N. Functionalization of carbon nanomaterials surface by Doxorubicin and antibodies to tumor markers // Nanoscale Research Letters. - 2016. - 11(1):314. DOI: 10.1186/s11671-016-1537-z. IF = 2.833.
2. Nesterenko O.M., Herheliuk T.S., Perepelytsina O.M., Sydorenko M.V., Bakalinska O.M., Ostapchenko L.I. Investigation of the degree of binding and controlled release of doxorubicin from the UDD and OLC // Proceedings of Ukrainian Conference with Internetional participationn "Chemistry, physics and technology of surface" and Workshop "Nanostructured biocompatible/bioactive material". - P. 112. 24-25 May, 2017. Kyiv, Ukraine.
3. Nesterenko O.M., Herheliuk T.S., Perepelytsina O.M., Sydorenko M.V., Bakalinska O.M., Ostapchenko L.I. Investigation of the effectiveness of carbon nanotubes for targeted delivery of antitumor drugs, International research and practice conference: Nanotechnology and Nanomaterials (NANO-2017), August 23-26, 2017, p. 636, Chernivtsi, Ukraine.
Together with the Institute of Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine:
DU VBTPD IPKK NAS of Ukraine is a joint challenge researcher of the scientific project "Biosafety and efficiency of the interaction of nanoparticles of inert metals with mesenchymal stem cells of the bone marrow" of the targeted complex program of basic research "Fundamental problems of creating new nanomaterials and nanotechnologies" of the National Academy of Sciences of Ukraine (2015-2019). The scientific leader of the project from the Department of VBTPD of the National Academy of Sciences of Ukraine is Doctor of Medicine. M.V. Sydorenko: in terms of the implementation of tasks 2015-2019
1. Pavlovich E., Volkova N., Yakymchuk E., Perepelytsina O., Sydorenko M., Goltsev A. In Vitro Study of Influence of Au Nanoparticles on HT29 and SPEV Cell Lines // Nanoscale Research Letters 2017 Aug 15;12( 1):494. doi: 10.1186/s11671-017-2264-9.
In cooperation with the Special Design and Technology Bureau and Research Production of the Institute of Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine (Kharkiv) within the framework of the topic "Investigation of the phenomenon of ultra-fast cooling of biological objects for the creation of a device for cryopreservation", a model of the device for cryopreservation was developed. As a result of the research, 2 patents were obtained for the utility model "Method of cryopreservation of somatic cells" No. 117693 (u201612432, published on July 10, 2017) and the patent for the utility model "Medium for cryopreservation of somatic cells" No. 117694 (u201612433, published on July 10, 2017). published article:
1. Perepelytsina O., Ugnivenko A., Burlaka D., Bezugly S., Sydorenko M. Optimization of human somatic cells cryopreservation protocols by polyethylene glycols // Medical and clinical chemistry. - 2016. - Vol. 18, No. 3. - P. 5-12.
In cooperation with the research department of head and neck tumors of the National Cancer Institute of the Ministry of Health of Ukraine:
The research staff of the State Technical University of the National Academy of Sciences of Ukraine carried out the research topic "Investigation of the expression of marker proteins of epithelial stem and progenitor cells in oral cavity cancer". Research results are published in scientific publications of Ukraine:
1. Yurchenko N.P., Kireeva S.S., Sydorenko M.V., Pershko N.Yu., Protsyk V.S. Changes in the mucous membrane of the oral cavity at a distance from the formed tumor in patients with squamous cell cancer and in persons from the risk group // Rhinology. - 2013. - No. 2. - Page 35-40.
2. Kireeva S.S., Yurchenko N.P., Sydorenko M.V., Pershko N.Yu., Protsyk V.S. Expression of marker proteins of epithelial stem and progenitor cells: regulatory nuclear protein p63 and cytokeratins SK5/14 in the epithelium of the mucous membrane of the oral cavity in precancerous conditions // Journal of Ear, Nose and Throat Diseases. - 2014. - No. 1. - Page 8-16.
The Department of Marker Compounds of the Department of Clinical Radiology of the National Academy of Sciences of Ukraine cooperates with the Institute of Clinical Radiology of the Scientific Center of Radiation Medicine of the National Academy of Sciences of Ukraine within the framework of the implementation of the National Development Program "Investigate the informativeness of albumin-calcium complexes of blood as potential markers in oncological pathology." The results of the work are presented in a professional scientific publication:
1. Ponomaryov I.O., Sydorenko M.V., Levchenko O.E., Pershko N.Yu., Burlaka D.P. // Methods of evaluating the results of spectrometric studies of biological objects in experiments and clinics. // Experimental and clinical physiology and biochemistry. - 2012. - No. 2. - Pages 74-80.
The strategy of cooperation between the Department of Scientific Research of the National Academy of Sciences of the National Academy of Sciences of Ukraine and other institutions of the National Academy of Sciences of Ukraine and research institutions of other subordinates consists in the intensification of bilateral and multilateral contacts, the submission of joint research projects, etc., which will be based on the complementary expertise of various teams. With regard to cooperation with commercial partners, the goal of the VBTPD of the NAS of Ukraine is its active development, the implementation of farm contract topics, an increase in the share of such topics in the general budget of the institution, and the search for new partners for the commercialization of VBTPD developments.
VBTPD has established fruitful relations with such organizations of the National Academy of Sciences of Ukraine as the Institute of Surface Chemistry named after O.O. Chuyka, Institute of Metallophysics, Institute of Physics, SKTB "Institute of Cryobiology and Cryomedicine", National Cancer Institute (MoH of Ukraine), Ukrainian Medical and Stomatological Academy; NSC "Institute of Biology" of Kyiv National University named after Taras Shevchenko, National Institute of Applied Sciences of Lyon (France), which allowed not only to present the results of research in joint publications, but also to prepare applications for participation in international programs.
Young scientists of the State University "Department of Biotechnical Problems of Diagnostics of the Institute of Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine" undergo training of highly qualified scientific personnel at KNU named after T. Shevchenko through postgraduate studies at the expense of budget funding:
- M.Sc. Gergelyuk T.S. by the decision of the admissions committee and the rector's order No. 606-34 dated 09/28/2016 of Taras Shevchenko National University of Kyiv, he was enrolled as a graduate student of the Educational and Scientific Center "Institute of Biology" with a break from production in the specialty 091 — biology.
Nesterenko O.M. by the decision of the admissions committee and the rector's order No. 820-34 dated 23.11.2015 of Taras Shevchenko National University of Kyiv, he was enrolled as a postgraduate student of the Educational and Scientific Center "Institute of Biology" without a break from production in the specialty 03.00.04 — biochemistry.
DU VBTPD IPKK NAS of Ukraine is the executor of the joint project with KNU named after Taras Shevchenko of the scientific work of young scientists working (studying) in higher educational institutions and scientific institutions belonging to the sphere of management of the Ministry of Education and Culture and carried out at the expense of the funds of the general fund of the state budget, according to the topic (section): Development and implementation of new technologies and equipment for high-quality medical care, pharmaceuticals, disease prevention and treatment; biotechnology; project No. 95503 "Biocompatible water-soluble C60 fullerenes as antifibrotic and antineoplastic agents in malignant neoplasms". Order of the Ministry of Education and Culture of Ukraine No. 983 of July 3, 2017. on the announcement of the competitive selection in 2017 of projects of scientific works and scientific and technical (experimental) developments of young scientists.
Young scientists of the State University "Department of Biotechnical Problems of Diagnostics of the Institute of Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine" undergo training of highly qualified scientific personnel at KNU named after T. Shevchenko through postgraduate studies at the expense of budget funding.
As part of the dissertation work, articles were published in specialized scientific journals with a high impact factor:
1. Perepelitsina O.M., Yastrebova O.V., Yakymchuk O.M., Bezugliy S.V., Yurchenko N.P., Sydorenko M.V., Ostapchenko L.I. The effect of the cytosol of mesenchymal stem cells on the biochemical indicators of the blood of mice and the development of Ehrlich's adenocarcinoma // Buk. Med. Herald. - 2016. - Vol. 20, No. 4 (80). - P. 139-146.
2. Herheliuk T., Perepelytsina O., Sydorenko M., Yurchenko N., Ostapchenko L. Expression of tumor associated and epithelial-mesenchymal transition markers in 2D and 3D cell cultures of MCF-7 // EUREKA: Health Sciences. - 2016. - No. 6. - R. 37-44. DOI: 10.21303/2504-5679. 2016.00231.
3. Herheliuk T., Perepelytsina O., Yakymchuk O., Ostapchenko L., Sydorenko M. 41PThe in vitro and in vivo effects of mesenchymal stem cells on breast cancer cells // Annals of Oncology 28(suppl_1)·May 2017. DOI : 10.1093/annonc/mdx140.003.
4. Herheliuk T., Perepelytsina O., Ostapchenko L., Yakymchuk O., Sydorenko M. Comparison of biological properties of C-medium from mesenchymal stem cells on 2D and 3D cells cultures of MCF-7 // Collection of theses of the XII International Scientific conference of students and postgraduates "Youth and the progress of biology" - Lviv, April 25-27, 2017, Ukraine. - p. 243.
5. Ugnivenko A.P., Perepelitsina O.M., Sydorenko M.V., Ostapchenko L.I. Carbon nanotubes in delivery of bioactive substances // J. Bionanoscience. - 2017. - Vol. 11, No. 6 (17). - P. 531-547. doi.org/10.1166/jbns.2017.1475
In cooperation with scientists from the Faculty of Physics of the National University named after T.G. Shevchenko during the implementation of the National Research Development Program 0112U0055549 "Investigation of the effect of metal-containing and carbon nanomaterials as a pro-differentiation matrix during in vitro cell growth" within the framework of the target program: "Fundamental problems of nanostructured systems, nanomaterials, nanotechnologies" it was found that the nanoscale structure of carbon aggregates of onions, UDA, NT and C60 fullerenes contribute to the reduction
adhesion of cells to the substrate and affects the formation of multicellular aggregates. The correlation between the concentration of BNM and the size of cell spheroids is also confirmed by statistical calculations of the Pearson correlation coefficient. In addition, BNMs have different effects on absorption qualities, affecting the concentration of growth factors in the culture medium and, as a result, on the growth of the tumor culture. The research results are published in the international collection of scientific articles:
1. Perepelytsina O.M., Rud A.D., Gergeliuk T.S., Biliy M.M., Sydorenko M.V., Kiryan I.M. Biochemical and cytotoxic properties of ultra dispersed diamonds // Collection of Scientific Articles "Carbon Particles in Condensed Media" of the VII International Conference "Fullerenes and Nanostructures in Condensed Media", Minsk, Belarus, June 9-12, 2013 - Page 334-339.
In cooperation with scientists from the Faculty of Chemistry of the National University named after T. Shevchenko during the implementation of the National Research Development Program 0112U0055549 "Investigation of the influence of metal-containing and carbon nanomaterials as a pro-differentiation matrix during in vitro cell cultivation" within the framework of the target program: "Fundamental problems of nanostructured systems, nanomaterials, nanotechnologies" the specifics of the influence of nanostructured materials on tumor cell culture models were determined in depending on the physical and chemical parameters of carbon aggregates. The research results were published in an international journal with a high impact factor:
1. Perepelytsina O.M., Sydorenko M.V., Yakymchuk O.M., Dobrydnev A.V. Effect of single-walled carbon nanotubes on tumor cell viability and formation of multicellular tumor spheroids. Nanoscale Research Letters 10(1):150, 2015. DOI: 10.1186/s11671-015-0858-7. IF = 2.833.
In cooperation with the Institute of Metallophysics named after H.V. Kurdyumov of the National Academy of Sciences of Ukraine:
The scientific staff of the VBTPD IPCC of the National Academy of Sciences of Ukraine were involved in the implementation of the scientific project "Investigation of the effect of metal-containing and carbon nanomaterials as a pro-differentiation matrix during cell growth in vitro" of the targeted comprehensive program of fundamental research "Fundamental problems of nanostructured systems, nanomaterials, nanotechnologies" of the National Academy of Sciences of Ukraine for 2010-2014 yr. in terms of performance of works/tasks. The scientific leader of the project from the Department of VBTPD of the National Academy of Sciences of Ukraine is Doctor of Medicine. Sydorenko M.V. (detailed information in section 3.1. National and international scientific communities). Research results are presented in leading scientific journals with a high impact factor:
1. Yakymchuk O.M., Perepelitsina O.M., Rudy O.D., Kiryan I.M., Sydorenko M.V. Study of the influence of the microstructure of nanomaterials on the formation of multicellular spheroids by tumor cells // Nanosystems, nanomaterials, nanotechnologies. - 2013. - V. 11(4). - P. 757-768.
2. Perepelytsina O.M., Rud A.D., Gergeliuk T.S., Biliy M.M., Sydorenko M.V., Kiryan I.M. Biochemical and cytotoxic properties of ultra dispersed diamonds // Collection of Scientific Articles "Carbon Particles in Condensed Media" of the VII International Conference "Fullerenes and Nanostructures in Condensed Media", Minsk, Belarus, June 9-12, 2013 - Page. 334-339.
3. Yakymchuk O.M., Perepelytsina O.M., Rud A.D., Kirian I.M., Sydorenko M.V. Impact of carbon nanomaterials on the formation of multicellular spheroids by tumor cells // Physica status solidi. - 2014. - P. 1-7 / DOI10.1002/psssa.201431358. IF = 1.775.
In cooperation with the Institute of Surface Chemistry named after O.O. Rumor:
the topic of scientific research works "Testing of a carbon-protein construct for the targeted delivery of anticancer drugs" of the target complex interdisciplinary scientific research program of the National Academy of Sciences of Ukraine "Molecular and cellular biotechnologies for the needs of medicine, industry and agriculture" is being carried out. Scientific supervisor — Doctor of Medicine. Sydorenko M.V. The results of joint research are presented in an international journal with a high impact factor:
1. Perepelytsina O.M., Yakymchuk O.M., Sydorenko M.V., Bakalinska O.N. Functionalization of carbon nanomaterials surface by Doxorubicin and antibodies to tumor markers // Nanoscale Research Letters. - 2016. - 11(1):314. DOI: 10.1186/s11671-016-1537-z. IF = 2.833.
2. Nesterenko O.M., Herheliuk T.S., Perepelytsina O.M., Sydorenko M.V., Bakalinska O.M., Ostapchenko L.I. Investigation of the degree of binding and controlled release of doxorubicin from the UDD and OLC // Proceedings of Ukrainian Conference with Internetional participationn "Chemistry, physics and technology of surface" and Workshop "Nanostructured biocompatible/bioactive material". - P. 112. 24-25 May, 2017. Kyiv, Ukraine.
3. Nesterenko O.M., Herheliuk T.S., Perepelytsina O.M., Sydorenko M.V., Bakalinska O.M., Ostapchenko L.I. Investigation of the effectiveness of carbon nanotubes for targeted delivery of antitumor drugs, International research and practice conference: Nanotechnology and Nanomaterials (NANO-2017), August 23-26, 2017, p. 636, Chernivtsi, Ukraine.
Together with the Institute of Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine:
DU VBTPD IPKK NAS of Ukraine is a joint challenge researcher of the scientific project "Biosafety and efficiency of the interaction of nanoparticles of inert metals with mesenchymal stem cells of the bone marrow" of the targeted complex program of basic research "Fundamental problems of creating new nanomaterials and nanotechnologies" of the National Academy of Sciences of Ukraine (2015-2019). The scientific leader of the project from the Department of VBTPD of the National Academy of Sciences of Ukraine is Doctor of Medicine. M.V. Sydorenko: in terms of the implementation of tasks 2015-2019
1. Pavlovich E., Volkova N., Yakymchuk E., Perepelytsina O., Sydorenko M., Goltsev A. In Vitro Study of Influence of Au Nanoparticles on HT29 and SPEV Cell Lines // Nanoscale Research Letters 2017 Aug 15;12( 1):494. doi: 10.1186/s11671-017-2264-9.
In cooperation with the Special Design and Technology Bureau and Research Production of the Institute of Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine (Kharkiv) within the framework of the topic "Investigation of the phenomenon of ultra-fast cooling of biological objects for the creation of a device for cryopreservation", a model of the device for cryopreservation was developed. As a result of the research, 2 patents were obtained for the utility model "Method of cryopreservation of somatic cells" No. 117693 (u201612432, published on July 10, 2017) and the patent for the utility model "Medium for cryopreservation of somatic cells" No. 117694 (u201612433, published on July 10, 2017). published article:
1. Perepelytsina O., Ugnivenko A., Burlaka D., Bezugly S., Sydorenko M. Optimization of human somatic cells cryopreservation protocols by polyethylene glycols // Medical and clinical chemistry. - 2016. - Vol. 18, No. 3. - P. 5-12.
In cooperation with the research department of head and neck tumors of the National Cancer Institute of the Ministry of Health of Ukraine:
The research staff of the State Technical University of the National Academy of Sciences of Ukraine carried out the research topic "Investigation of the expression of marker proteins of epithelial stem and progenitor cells in oral cavity cancer". Research results are published in scientific publications of Ukraine:
1. Yurchenko N.P., Kireeva S.S., Sydorenko M.V., Pershko N.Yu., Protsyk V.S. Changes in the mucous membrane of the oral cavity at a distance from the formed tumor in patients with squamous cell cancer and in persons from the risk group // Rhinology. - 2013. - No. 2. - Page 35-40.
2. Kireeva S.S., Yurchenko N.P., Sydorenko M.V., Pershko N.Yu., Protsyk V.S. Expression of marker proteins of epithelial stem and progenitor cells: regulatory nuclear protein p63 and cytokeratins SK5/14 in the epithelium of the mucous membrane of the oral cavity in precancerous conditions // Journal of Ear, Nose and Throat Diseases. - 2014. - No. 1. - Page 8-16.
The Department of Marker Compounds of the Department of Clinical Radiology of the National Academy of Sciences of Ukraine cooperates with the Institute of Clinical Radiology of the Scientific Center of Radiation Medicine of the National Academy of Sciences of Ukraine within the framework of the implementation of the National Development Program "Investigate the informativeness of albumin-calcium complexes of blood as potential markers in oncological pathology." The results of the work are presented in a professional scientific publication:
1. Ponomaryov I.O., Sydorenko M.V., Levchenko O.E., Pershko N.Yu., Burlaka D.P. // Methods of evaluating the results of spectrometric studies of biological objects in experiments and clinics. // Experimental and clinical physiology and biochemistry. - 2012. - No. 2. - Pages 74-80.
The strategy of cooperation between the Department of Scientific Research of the National Academy of Sciences of the National Academy of Sciences of Ukraine and other institutions of the National Academy of Sciences of Ukraine and research institutions of other subordinates consists in the intensification of bilateral and multilateral contacts, the submission of joint research projects, etc., which will be based on the complementary expertise of various teams. With regard to cooperation with commercial partners, the goal of the VBTPD of the NAS of Ukraine is its active development, the implementation of farm contract topics, an increase in the share of such topics in the general budget of the institution, and the search for new partners for the commercialization of VBTPD developments.
Development of a cellular test system for determining the effectiveness and mechanisms of action of anticancer drugs
Determination of the biosafety and cytotoxic effect of gold nanoparticles on monolayer and spheroid culture of tumor cells
Study of the effect of metal-containing and carbon nanomaterials as a matrix on cell growth in vitro
Study of pro- and anti-oncogenic activity of biological substances of cellular origin
