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Direction of scientific activity: study of absorption of electromagnetic waves by whole blood smears of patients with breast fibroadenomatosis and breast cancer in the IR range of 1700-1600 cm-1 (Amide I). Also, experimental spectral studies with the aim of identifying the difference in IR absorption of blood proteins of humans and animals in cancer. the efforts of employees are aimed at introducing the spectral characteristics of blood proteins into diagnostic practice. Long-term observations of clinical patients (breast cancer) confirm the high informativeness and prognostic value of blood protein spectra.
- The research activities. The Group has been researching the absorption of electromagnetic waves strokes of whole blood of patients with breast cancer and fibroadenomatosis mammae in infrared 1600sm-1700-1 (Amide I). Also experimental spectral studies to detect differences in the IR absorption of protein levels in human and animal cancers. The efforts of the staff are aimed at introducing the spectral characteristics of blood proteins into practice. Long-term observations of clinical patients (breast cancer) confirm the high informative value and prognostic value of the spectra of blood proteins.
Projects implemented by the Group:
"Investigate the informativeness of albumin-calcium complexes of blood as potential markers in oncological pathology" (Performance period 2008 - 2012)
Publications:
1. Sydorenko M.V., Levchenko O.E., Ponomaryov I.O., Pelevin S.V., Burlaka D.P. Computer program "Program for automated data processing of spectrometry "Spectra infra". Certificate of state registration of the author's rights to the work PA No. 16679. Registered in the State Department of Intellectual Property of Ukraine on May 19, 2006.
2. Korytskaya L.N. Chapter 9 "Prevention of fibroadenomatosis and breast cancer" p. 330-375 in the book: Yalkut S.I. Prevention of tumors. M. Book Plus, 2006.
3. Burlaka D., Levchenko O., Korytska L., Sidorenko M. IR-spectrum of blood and redox: diagnostics of cancer. on 5th International Conference Cancer Prevention (Advances in Molecular and Clinical Aspects of Cancer Prevention) 6-8 March 2008, University of St.Gallen/ Switzerland.
4. Burlaka D.P., Steblyanko T.I., Levchenko O.E., Korytska L.M., Sydorenko M.V. Stand presentation: Study of the state of thiol groups in blood and its serum by analyzing IR spectra in the Amide I band for the purpose of diagnosing cancer. Ukraine, Kharkiv. 2009.
5. D. Burlaka, O. Klenov, S. Zaletok Affinity of extracts of soy to estrogen receptors and their antiestrogenic influence on mammary tumors mice C3H/Sn. Zurich, Switzerland 20–21 March 2009 23P
6. Levchenko O.E., Ponomomaryov I.O., Pelevin S.V., Burlaka D.P., Korytska L.M., Sydorenko M.V. A new approach to the diagnosis of breast cancer and fibroadenomatosis. Abstracts of the II All-Ukrainian scientific and practical conference "Modern methodological approaches to the analysis of the state of health" (March 17-18, 2008) Luhansk, 2008, p. 57
7. D. Burlaka, L. Korizkaja, O. Levtchenko, S. Pelevin, M. Sidorenko. Using infrared spectra of blood for earlier diagnosis of breast cancer and fibroadenomatosis. Annales Universitatis Mariae Curie-Sklodowska. 2008.
8. Levchenko O.E., Pelevin S.V., Melnyk V.O., Sydorenko M.V. Dependence of the IR spectral characteristics of albumin on its concentration in the solution. Abstracts of the International scientific conference "Biophysical mechanisms of functioning of living systems" (October 16-18, 2008).
9. Burlaka D. The animal model for development of primary hormone therapy of a breast cancer” on Primary Therapy of Early Breast Cancer 10th International Conference 14-17 March 2007 St.Gallen /Switzerland.
10. Burlaka DP, Steblianko TI, Levchenko OE, Korytska LM, Sydorenko MV. Quantification - SH group level in blood by IR spectroscopic analysis. 35Th FEBS Congress Goteborg Sweden, June26-July1, 2010. Supplement of The FEBS Journal 2010, C3.01.
11. Burlaka DP, Steblianko TI, Levchenko OE, Korytska LM, Sydorenko MV. Spectral and biochemical data of the blood of mice with transplanted tumors. International conference "Tumor and host: novel aspects of an old problem" September 21-24, Kyiv, Ukraine. Experimental Oncology, v32, suppl. 2010.
12. Ponomaryov I.O., Sydorenko M.V., Levchenko O.E., Pershko N.Yu., Burlaka D.P. Methods of evaluating the results of spectrometric studies of biological objects in experiments and clinics. Experimental and clinical physiology and biochemistry.-2012.- No. 2, p. 74-80.
Scientific field of activity: – development of methods for measuring absorption spectra of thin films of blood and other biological substances in the mid-IR range and creation of appropriate equipment based on them, in particular, for the implementation of screening methods in risk groups for oncological diseases. In addition, in the context of the main areas of scientific activity, there is the introduction of free system and application software with open source code.
Publications:
1. Certificate of copyright registration for work No. 57553 "Steroid Cont" reproducibility control program. Authors: Pershko N.P., Kulikov V.M., Sydorik E.P., Melnyk V.O., Levchenko O.E. Date of registration 09.12.2014.
2. Levchenko O.E., Pelevyn S.V., Burlaka D.P., Pershko N.Yu., Korytskaya L.N., Sydorenko M.V. Application of IR spectrometry of thin films of biological substances for express screening of cancer patients // Scientific and practical virtual conference "Spectrometric methods of analysis" at www.paxgrid.ru/conference, September 26, 2013.
3. Levchenko O.E., Pelevyn S.V., Pershko N.Yu., Korytskaya L.N., Sydorenko M.V. Free software in the field of biotechnology as a way to save budget funds: the experience of creating a software and technical complex for spectral studies // II International scientific and practical virtual conference "Mathematical and computer modeling in biology and chemistry. Development prospects" at www.paxgrid.ru/conference, September 24, 2013.
"Creation of a hardware and software complex for spectral research of thin films of biological substances in the mid-IR range" (Performance period: 2015-2018)
Publications:
1. Pershko N.Yu., Levchenko O.E., Burlaka D.P., Ponomareva O.V., Sydorenko M.V., Sydorik E.P. Screening approaches in oncology based on infrared spectroscopy // Ukrainian Radiological Journal: Proceedings of the XIII Congress of Oncologists and Radiologists of Ukraine, Appendix 1, p. 194, 2016, Kyiv, Ukraine.
2. Pershko N., Levchenko O., Sidorenko M., Fedorenko. Reseath of albumin-calcium complex in blood of patient with malignant tumors as a possible markers of oncopathology // 7-th Lviv-Lublin conference of Experimental and Clinical Biochemical, Abstract book May 23-24, Lviv, Ukraine. - 2013.- S.149.
[Electronic resource] — 16 publications.
1. Levchenko O.E. BiDiPro, Linux, DOS-applications, LPT-port and everything-everything-everything (Part 1. Ubuntu) [Electronic resource]. – Mar 2012. https://www.researchgate.net/publication/301647084_BiDiPro_Linux_DOS-prilozenia_LPT-port_i_vse-vse-vse_Cast_1_Ubuntu (Date of access: 08/05/2017).
2. Levchenko O.E. DOSEMU and direct access to LPT ports (Part 2. Scientific Linux) [Electronic resource]. – February 2013.
https://www.researchgate.net/publication/301647173_DOSEMU_i_pramoj_dostup_k_LPT-portam_Cast_2_Scientific_Linux (Date of access: 08/05/2017)
3. Levchenko O.E. MTP under Scientific Linux 6. [Electronic resource]. – September 2013. https://www.researchgate.net/publication/301651215_MTP_pod_Scientific_Linux_6 (Date of access: 08/05/2017)
4. Levchenko O.E. Text recognition (OCR) under Scientific Linux 6
[Electronic resource]. – November 2013. https://www.researchgate.net/publication/30165100 Raspoznavanie_teksta_OCR_pod_Scientific_Linux_6
(Date of application: 05.08.2017)
5. Levchenko O.E. Installing the Google Chrome browser under Scientific Linux 6 [Electronic resource]. – November 2013.
https://www.researchgate.net/publication/301661210_Ustanovka_brauzera_Google_Chrome_pod_Scientific_Linux_6
(Date of application: 08/05/2017)
6. Levchenko O.E. Old ZyXEL P660RT2,
Ukrtelecom and the DHCP/iPoE protocol [Electronic resource]. – February 2014.
https://www.researchgate.net/publication/301677663_Staryj_ZyXEL_P660RT2_Ukrtelekom_i_protokol_DHCPiPoE (Date of access: 08/05/2017)
7. Levchenko O.E. Installing native Steam under Scientific Linux 6 [Electronic resource]. – August 2014. https://www.researchgate.net/publication/301671109 Ustanovka_nativnogo_Steam_pod_Scientific_Linux_6 (Date of application: 08/05/2017)
8. Levchenko O.E. Installing Kompas-3D under Wine (some personal experience) [Electronic resource]. – December 2014.
https://www.researchgate.net/publication/301677538 Ustanovka_Kompas-3D_pod_Wine_nemnogo_licnogo_opyta (Date of access: 08/05/2017)
9. Levchenko O.E. Installing Kompas-3D under Wine (some personal experience) [Electronic resource]. – December 2014.
https://www.researchgate.net/publication/301677538_Ustanovka_Kompas-3D_pod_Wine_nemnogo_licnogo_opyta (Date of access: 08/05/2017)
10. Levchenko O.E. Installing Kingsoft WPS Office for Scientific Linux 6 (CentOS 6, RHEL 6, etc.) [Electronic resource]. – March 2015.
https://www.researchgate.net/publication/301687610 Ustanovka_Kingsoft_WPS_Office_pod_Scientific_Linux_6_CentOS_6_RHEL_6_i_tp (Access date: 08/05/2017)
11. Levchenko O.E. Bravis i60 reader is back to life [Electronic resource]. – July 2015. https://www.researchgate.net/publication/301677730 Vozvrasaem_k_zizni_citalku (Date of access: 08/05/2017)
12. Levchenko O.E. Installing Scientific Linux 6 on a Dell Inspiron laptop
7537 [Electronic resource]. – September 2015.
https://www.researchgate.net/publication/301688308_
Ustanovka_Scientific_Linux_6_na_noutbuk_Dell_Inspiron_7537 (Date of application: 08/05/2017)
13. Levchenko O.E. Strange interference from the scanner's power supply [Electronic resource]. – December 2015.
https://www.researchgate.net/publication/301692483_Strannaa_pomeha_ot_BP_skanera (Date of access: 08/05/2017)
14. Levchenko O.E. Experience installing printer HP Scanjet 3770 pod
Scientific Linux 6 [Electronic resource]. – January 2016.
https://www.researchgate.net/publication/301692479_Opyt_ustanovki_skanera_HP_Scanjet_3770_pod_Scientific_Linux 6
(Date of application: 05.08.2017)
15. Levchenko O.E. We add support for glibc-2.17 and GLIBCXX_3.4.19
Scientific Linux 6 [Electronic resource]. – November 2016.
https://www.researchgate.net/publication/311572016_Dobavlaem_podderzku_glibc-217_i_GLIBCXX_3419_v_Scientific_Linux_6 (Date of access: 08/05/2017)
16. Levchenko O.E. If the ZyXEL P660RT2 EE loses packets...
[Electronic resource]. – April 2017. https://www.researchgate.net/publication/315793097_
Esli_ZyXEL_P660RT2_EE_teraet_pakety (Date of access: 08/05/2017)
- The research activities. The Group has been researching the absorption of electromagnetic waves strokes of whole blood of patients with breast cancer and fibroadenomatosis mammae in infrared 1600sm-1700-1 (Amide I). Also experimental spectral studies to detect differences in the IR absorption of protein levels in human and animal cancers. The efforts of the staff are aimed at introducing the spectral characteristics of blood proteins into practice. Long-term observations of clinical patients (breast cancer) confirm the high informative value and prognostic value of the spectra of blood proteins.
Projects implemented by the Group:
"Investigate the informativeness of albumin-calcium complexes of blood as potential markers in oncological pathology" (Performance period 2008 - 2012)
Publications:
1. Sydorenko M.V., Levchenko O.E., Ponomaryov I.O., Pelevin S.V., Burlaka D.P. Computer program "Program for automated data processing of spectrometry "Spectra infra". Certificate of state registration of the author's rights to the work PA No. 16679. Registered in the State Department of Intellectual Property of Ukraine on May 19, 2006.
2. Korytskaya L.N. Chapter 9 "Prevention of fibroadenomatosis and breast cancer" p. 330-375 in the book: Yalkut S.I. Prevention of tumors. M. Book Plus, 2006.
3. Burlaka D., Levchenko O., Korytska L., Sidorenko M. IR-spectrum of blood and redox: diagnostics of cancer. on 5th International Conference Cancer Prevention (Advances in Molecular and Clinical Aspects of Cancer Prevention) 6-8 March 2008, University of St.Gallen/ Switzerland.
4. Burlaka D.P., Steblyanko T.I., Levchenko O.E., Korytska L.M., Sydorenko M.V. Stand presentation: Study of the state of thiol groups in blood and its serum by analyzing IR spectra in the Amide I band for the purpose of diagnosing cancer. Ukraine, Kharkiv. 2009.
5. D. Burlaka, O. Klenov, S. Zaletok Affinity of extracts of soy to estrogen receptors and their antiestrogenic influence on mammary tumors mice C3H/Sn. Zurich, Switzerland 20–21 March 2009 23P
6. Levchenko O.E., Ponomomaryov I.O., Pelevin S.V., Burlaka D.P., Korytska L.M., Sydorenko M.V. A new approach to the diagnosis of breast cancer and fibroadenomatosis. Abstracts of the II All-Ukrainian scientific and practical conference "Modern methodological approaches to the analysis of the state of health" (March 17-18, 2008) Luhansk, 2008, p. 57
7. D. Burlaka, L. Korizkaja, O. Levtchenko, S. Pelevin, M. Sidorenko. Using infrared spectra of blood for earlier diagnosis of breast cancer and fibroadenomatosis. Annales Universitatis Mariae Curie-Sklodowska. 2008.
8. Levchenko O.E., Pelevin S.V., Melnyk V.O., Sydorenko M.V. Dependence of the IR spectral characteristics of albumin on its concentration in the solution. Abstracts of the International scientific conference "Biophysical mechanisms of functioning of living systems" (October 16-18, 2008).
9. Burlaka D. The animal model for development of primary hormone therapy of a breast cancer” on Primary Therapy of Early Breast Cancer 10th International Conference 14-17 March 2007 St.Gallen /Switzerland.
10. Burlaka DP, Steblianko TI, Levchenko OE, Korytska LM, Sydorenko MV. Quantification - SH group level in blood by IR spectroscopic analysis. 35Th FEBS Congress Goteborg Sweden, June26-July1, 2010. Supplement of The FEBS Journal 2010, C3.01.
11. Burlaka DP, Steblianko TI, Levchenko OE, Korytska LM, Sydorenko MV. Spectral and biochemical data of the blood of mice with transplanted tumors. International conference "Tumor and host: novel aspects of an old problem" September 21-24, Kyiv, Ukraine. Experimental Oncology, v32, suppl. 2010.
12. Ponomaryov I.O., Sydorenko M.V., Levchenko O.E., Pershko N.Yu., Burlaka D.P. Methods of evaluating the results of spectrometric studies of biological objects in experiments and clinics. Experimental and clinical physiology and biochemistry.-2012.- No. 2, p. 74-80.
Scientific field of activity: – development of methods for measuring absorption spectra of thin films of blood and other biological substances in the mid-IR range and creation of appropriate equipment based on them, in particular, for the implementation of screening methods in risk groups for oncological diseases. In addition, in the context of the main areas of scientific activity, there is the introduction of free system and application software with open source code.
Publications:
1. Certificate of copyright registration for work No. 57553 "Steroid Cont" reproducibility control program. Authors: Pershko N.P., Kulikov V.M., Sydorik E.P., Melnyk V.O., Levchenko O.E. Date of registration 09.12.2014.
2. Levchenko O.E., Pelevyn S.V., Burlaka D.P., Pershko N.Yu., Korytskaya L.N., Sydorenko M.V. Application of IR spectrometry of thin films of biological substances for express screening of cancer patients // Scientific and practical virtual conference "Spectrometric methods of analysis" at www.paxgrid.ru/conference, September 26, 2013.
3. Levchenko O.E., Pelevyn S.V., Pershko N.Yu., Korytskaya L.N., Sydorenko M.V. Free software in the field of biotechnology as a way to save budget funds: the experience of creating a software and technical complex for spectral studies // II International scientific and practical virtual conference "Mathematical and computer modeling in biology and chemistry. Development prospects" at www.paxgrid.ru/conference, September 24, 2013.
"Creation of a hardware and software complex for spectral research of thin films of biological substances in the mid-IR range" (Performance period: 2015-2018)
Publications:
1. Pershko N.Yu., Levchenko O.E., Burlaka D.P., Ponomareva O.V., Sydorenko M.V., Sydorik E.P. Screening approaches in oncology based on infrared spectroscopy // Ukrainian Radiological Journal: Proceedings of the XIII Congress of Oncologists and Radiologists of Ukraine, Appendix 1, p. 194, 2016, Kyiv, Ukraine.
2. Pershko N., Levchenko O., Sidorenko M., Fedorenko. Reseath of albumin-calcium complex in blood of patient with malignant tumors as a possible markers of oncopathology // 7-th Lviv-Lublin conference of Experimental and Clinical Biochemical, Abstract book May 23-24, Lviv, Ukraine. - 2013.- S.149.
[Electronic resource] — 16 publications.
1. Levchenko O.E. BiDiPro, Linux, DOS-applications, LPT-port and everything-everything-everything (Part 1. Ubuntu) [Electronic resource]. – Mar 2012. https://www.researchgate.net/publication/301647084_BiDiPro_Linux_DOS-prilozenia_LPT-port_i_vse-vse-vse_Cast_1_Ubuntu (Date of access: 08/05/2017).
2. Levchenko O.E. DOSEMU and direct access to LPT ports (Part 2. Scientific Linux) [Electronic resource]. – February 2013.
https://www.researchgate.net/publication/301647173_DOSEMU_i_pramoj_dostup_k_LPT-portam_Cast_2_Scientific_Linux (Date of access: 08/05/2017)
3. Levchenko O.E. MTP under Scientific Linux 6. [Electronic resource]. – September 2013. https://www.researchgate.net/publication/301651215_MTP_pod_Scientific_Linux_6 (Date of access: 08/05/2017)
4. Levchenko O.E. Text recognition (OCR) under Scientific Linux 6
[Electronic resource]. – November 2013. https://www.researchgate.net/publication/30165100 Raspoznavanie_teksta_OCR_pod_Scientific_Linux_6
(Date of application: 05.08.2017)
5. Levchenko O.E. Installing the Google Chrome browser under Scientific Linux 6 [Electronic resource]. – November 2013.
https://www.researchgate.net/publication/301661210_Ustanovka_brauzera_Google_Chrome_pod_Scientific_Linux_6
(Date of application: 08/05/2017)
6. Levchenko O.E. Old ZyXEL P660RT2,
Ukrtelecom and the DHCP/iPoE protocol [Electronic resource]. – February 2014.
https://www.researchgate.net/publication/301677663_Staryj_ZyXEL_P660RT2_Ukrtelekom_i_protokol_DHCPiPoE (Date of access: 08/05/2017)
7. Levchenko O.E. Installing native Steam under Scientific Linux 6 [Electronic resource]. – August 2014. https://www.researchgate.net/publication/301671109 Ustanovka_nativnogo_Steam_pod_Scientific_Linux_6 (Date of application: 08/05/2017)
8. Levchenko O.E. Installing Kompas-3D under Wine (some personal experience) [Electronic resource]. – December 2014.
https://www.researchgate.net/publication/301677538 Ustanovka_Kompas-3D_pod_Wine_nemnogo_licnogo_opyta (Date of access: 08/05/2017)
9. Levchenko O.E. Installing Kompas-3D under Wine (some personal experience) [Electronic resource]. – December 2014.
https://www.researchgate.net/publication/301677538_Ustanovka_Kompas-3D_pod_Wine_nemnogo_licnogo_opyta (Date of access: 08/05/2017)
10. Levchenko O.E. Installing Kingsoft WPS Office for Scientific Linux 6 (CentOS 6, RHEL 6, etc.) [Electronic resource]. – March 2015.
https://www.researchgate.net/publication/301687610 Ustanovka_Kingsoft_WPS_Office_pod_Scientific_Linux_6_CentOS_6_RHEL_6_i_tp (Access date: 08/05/2017)
11. Levchenko O.E. Bravis i60 reader is back to life [Electronic resource]. – July 2015. https://www.researchgate.net/publication/301677730 Vozvrasaem_k_zizni_citalku (Date of access: 08/05/2017)
12. Levchenko O.E. Installing Scientific Linux 6 on a Dell Inspiron laptop
7537 [Electronic resource]. – September 2015.
https://www.researchgate.net/publication/301688308_
Ustanovka_Scientific_Linux_6_na_noutbuk_Dell_Inspiron_7537 (Date of application: 08/05/2017)
13. Levchenko O.E. Strange interference from the scanner's power supply [Electronic resource]. – December 2015.
https://www.researchgate.net/publication/301692483_Strannaa_pomeha_ot_BP_skanera (Date of access: 08/05/2017)
14. Levchenko O.E. Experience installing printer HP Scanjet 3770 pod
Scientific Linux 6 [Electronic resource]. – January 2016.
https://www.researchgate.net/publication/301692479_Opyt_ustanovki_skanera_HP_Scanjet_3770_pod_Scientific_Linux 6
(Date of application: 05.08.2017)
15. Levchenko O.E. We add support for glibc-2.17 and GLIBCXX_3.4.19
Scientific Linux 6 [Electronic resource]. – November 2016.
https://www.researchgate.net/publication/311572016_Dobavlaem_podderzku_glibc-217_i_GLIBCXX_3419_v_Scientific_Linux_6 (Date of access: 08/05/2017)
16. Levchenko O.E. If the ZyXEL P660RT2 EE loses packets...
[Electronic resource]. – April 2017. https://www.researchgate.net/publication/315793097_
Esli_ZyXEL_P660RT2_EE_teraet_pakety (Date of access: 08/05/2017)
Development of a cellular test system for determining the effectiveness and mechanisms of action of anticancer drugs
Determination of the biosafety and cytotoxic effect of gold nanoparticles on monolayer and spheroid culture of tumor cells
Study of the effect of metal-containing and carbon nanomaterials as a matrix on cell growth in vitro
Study of pro- and anti-oncogenic activity of biological substances of cellular origin
