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The scientific direction of research is the study of the biology of cells that express marker proteins of epithelial stem and progenitor cells (cancer stem cells) during the formation of a transformed phenotype in the oral mucosa of persons at risk of cancer (tobacco smoking), in precancerous conditions and in the progression of squamous cell carcinoma.
The proteome research group is studying changes in the expression profile of biomarker proteins p53 Ki-67, Bcl-2 and marker proteins of epithelial stem cells p63, Cк5/14, CD44, ALDH1, in the cell layers of the squamous epithelium of the oral mucosa during the formation of a transformed phenotype; epithelial-mesenchymal transition (EMT) in squamous cell carcinoma of the oral cavity during invasion and progression of the tumor process.
- Priority is to study the biology of cells that expressed marker proteins of the epithelial stem cells in formation of the transformed phenotype in oral mucosa of persons with cancer risk (smoking habits), precancerous lesions and progression of the oral squamous cell carcinoma.
Proteome research group studies changes in the profile of expression of biomarker proteins p53, Ki-67, Bcl-2 and marker proteins of epithelial stem cells p63, Ck5/14, CD44, ALDHI, in cell layers of the squamous epithelium of oral mucosa in the formation of the transformed phenotype; and epithelial-mesenchymal transition (EMT) in the oral squamous cell carcinoma (OSCC) in invasion and progression of the tumor process.
Projects implemented by the Laboratory:
"Investigation of the condition of the epithelium of the oral mucosa and the biology of basal cells during the formation of a transformed phenotype" (Performance period 2007 - 2011
Publications:
1. Kireeva S.S., Lisnyk I.O., Yurchenko N.P., Protsyk V.S., Sydorenko M.V. Expression of p53 and VEGF in oral cavity cancer patients // Journal of Ear, Nose and Throat Diseases. - 2008. - No. 4. - Page 52-57.
2. Borodai N.V., Sydorenko M.V., Yurchenko N.P., Datsyuk I.O. Densiometric parameters of the nuclei of cells of the mucous cavity and tumor cells in histological sections of biopsies of the epithelium at a distance from the tumor and the tumor in patients with cancer of the oral cavity // Journal of Ear, Nose and Throat Diseases. - 2008. - No. 4. - Page 6-10.
3. Kireeva S.S., Protsyk V.S., Yurchenko N.P., Osadcha O.M., Sydorenko M.V. Profile of proteins p53, Bsl-2, Ki-67 and changes in mucosal epithelium at a distance from the formed tumor in patients with oral cavity cancer // Journal of Ear, Nose and Throat Diseases. - 2010. - No. 4. - Page 57-59.
4. Kireeva S.S., Yurchenko N.P., Ishchenko V.V., Skrypnikova T.P., Bashtan V.P. p53 and Ki-67 as biomarkers for the objectification of histological diagnosis of precancerous conditions and cancer of the oral mucosa on biopsy material // Problems of ecology and medicine. - 2010. - Vol. 14, No. 3-4. - Pages 17-21.
5. Kireeva S.S., Lisnyak I.O., Yurchenko N.P., Protsyk V.S., Sydorenko M.V. Susceptibility of cultured lymphocytes to the mutagen bleomycin and the state of the mucosal epithelium at a distance from the formed tumor in patients with oral cavity cancer // Journal of Ear, Nose and Throat Diseases. - 2010. - No. 2. - Page 7-12.
6. Kireeva S.S., Yurchenko N.P., Ishchenko V.V., Protsyk V.S., Sydorenko M.V. Changes in the mucosa at a distance from the formed tumor and the profile of p53 and Ki-67 proteins in the cell layers of the mucosa epithelium in patients with squamous cell carcinoma of the oral cavity // Problems of ecology and medicine. - 2010. - Vol. 14, No. 3-4. - Page 17-21.
7. Kireeva S.S., Yurchenko N.P., Yakshibaeva Yu.R., Sydorenko M.V., Protsyk V.S. Study of the sensitivity of the body of a patient with oral cavity cancer to the mutagen bleomycin and the expression of p53 and the state of the mucous epithelium at a distance from the developed tumor // Proceedings of the VIII Congress of the Ukrainian Society of Geneticists and Breeders of Ukraine named after E. Vavilova - Kyiv, Logos, 2007. - p. 455-459.
8. Osadcha O., Kireeva S., Yurchenko N. Alterations in distant oral mucosa and buccal epithelium in patients with OSCC and with epidemiological risk // 118th European students conference. 7-11 October 2007, Berlin, Germany. Medical faculty of Humboldt University and Free University of Berlin. P. 300.
10. Kireeva S., Osadcha O., Sydorenko M. p53, Bcl-2, Ki-67 expression and alteration in tumor-distantoral mucosa in patients with oral squamous cell carcinoma (P34) // 5th international conference cancer prevention. Advances in molecular and clinical aspects of cancer prevention. 6-8 March 2008, St. Gallen, Switzerland // Europ. J. Cancer. - 2008. - vol. 6 (3). - P. 52.
11. Kireeva S., Yurchenko N., Sydorenko M., Protsyk V. P63, CK14 and p53 expression in epithelial layers of tumor-distant oral mucosa in patients with oral squamous cell carcinoma (P7) // 6-th international conference on clinical cancer prevention. 18-20 March 2010, St. Gallen, Switzerland // Europ. J. Cancer. - 2010. - vol. 8 (2). - P. 12.
12. Kireeva S. Mutagen sensitivity and p53 in suprabasal layers of tumor-distant oral mucosa in patients with oral squamous cell carcinoma (P6) // 6th international conference on clinical cancer prevention. 18-20 March 2010, St. Gallen, Switzerland // Europ. J. Cancer. - 2010. - vol. 8 (2). - P. 12.
13. Kireeva S.S. V.S. Protsyk Non-invasive impression technology for the objectification of cytological diagnosis of precancerous conditions, cancer of the oral cavity, screening and monitoring // Clinical Oncology. Special issue of the 12th Congress of Oncologists of Ukraine (meeting materials), September 20-22, 2011. Sudak, Autonomous Republic of Krym, p. 34.
14. Bashtan V.P., Kireeva S.S., Skrypnikov M.P., Skrypnikova T.P., Ivashchenko V.V. Improving the efficiency of early diagnosis of precancerous conditions of the oral mucosa by the method of evaluating the expression of biomarker proteins p53 and Ki-67 // Clinical Oncology. Special issue of the 12th Congress of Oncologists of Ukraine (meeting materials), September 20-22, 2011. Sudak, Autonomous Republic of Krym, p. 27.
"Study of the expression of marker proteins of epithelial stem and progenitor cells in oral cavity cancer" (Performance period: 2012-2014
Publications:
1. N.V. Boroday, D.A. Klyushiv, Y.A. Petunin, O. Lyakhovka, F. Miropolsku, R.A. Andrushkiv. Retrospective cohort investigation of risk factors in breast cancer. METMBS " 04- Las Vegas, Nevada, 2004, 385-390.
2. S. Kirieieva, N. Yurchenko, V. Shukalevych, Yu. Yakshibayeva, M. Sidorenko, V. Protsyk. Serial cytological assay of buccal exfoliated cells as technology for mass screening of individuals at risk of oral cancer for monitoring and cancer prevention // Europ. J. Cancer. - 2006; 4 (1): 52-54.
3. N. Boroday, D. Klyushin, Y. Petunin, R. Andrushkiv. Analysis of malignancy-associated DNA changes in interphase nuclei of buccal epithelium with breast diseases // Experimental Oncology - 2004; 26 (2): 158-160.
4. S.S. Kireeva, O.I. Dasyukevich, D. P. Burlaka, V. B. Vynnytskyi. Peculiarities of hormonal and genetic homeostasis in men with gynecomastia and breast cancer // Bukovynsky Medical Bulletin. -.2002. - vol. 6 (1). - Page 55-59.
5. S.S. Kireeva, M.V. Sydorenko Cytogenetic changes in bone marrow cells of mice with different genotypes under the influence of therapeutic doses of cyclophosphane and cisplatin // Bukovynskyi medical bulletin. - 2006. - v. 10 (3). - Page 105-110.
6. S.S. Kireeva, N.P. Yurchenko, M.V. Sydorenko, N.Yu. Pershko, V.S. Protsik
"Expression of marker proteins of epithelial stem and progenitor cells: regulatory nuclear protein p63 and cytokeratins SK5/14 in the epithelium of the mucous membrane of the oral cavity in precancerous conditions // Journal of Ear, Nose and Throat Diseases. - 2014. - No. 1. - Page 8-16.
7. Kirieieva S., Yurchenko N., Sidorenko M., Pershko N. Suprabasal expression oh the marker proteins of the epithelial stem and progenitor cells p63, CD44 in precancerous lesions and oral mucosa from patients with risk of oral cancer // Collection of scientific Proceedings - International symposium on cell biology jointly with 4-th Ukrainian congress for cell biology. - September 17-20, 2014, Uzhhorod, Ukraine.
8. Yurchenko N.P., Kirieieva S.S., Sidorenko M.V., Pershko N.Yu., Protsyk V. Expression of marker proteins of the epithelial stem/progenitor cells p63, CK5/14 in oral mucosa from patients with precancerous lesions and oral cancer // Ukr . biochem. journal - 2014. - Vol. 86, No. 5 (Part 1). - Collection of scientific papers. - XI Ukrainian Biochemical Congress. - November 6-10, 2014, Kyiv, Ukraine.
9. Yurchenko N.P., Kireeva S.S., Sydorenko M.V., Pershko N.Yu., Protsyk V.S. "Changes in the mucous membrane of the oral cavity at a distance from the formed tumor in patients with squamous cell cancer and in persons from the risk group" // Rhinology. - 2013. - No. 2. - p. 35-40.
10. Pershko N., Levchenko O., Fedorenko O., Sidorenko M. Researching albumin-calcium complexes in blood with malignant tumors as a possible markers of oncopathology // 7th Lviv-Lublin Conference on Experimental and Clinical Biochemistry, 23 - May 24, 2013, Lviv, Ukraine.
11. Kokutsa R.V., Yurchenko N.P., Kireeva S.S. Assessment of changes in the mucous membrane of the oral cavity in persons at risk of cancer to monitor the effectiveness of preventive therapy in the conditions of polyclinic dental examination and treatment.// Proceedings of the International scientific and practical conference "Perspectives for the development of staged restorative treatment". - 03.2012.
"Investigate the epithelial-mesenchymal transition and its connection with tumor cells that express marker proteins of epithelial stem cells in oral cancer" (Performance period: 2012-2014)
Publications:
1. Yurchenko N., Kireieva S., Sidorenko M., Pershko N., Protsyk V., Boychuk A., Korolchuk O. The noninvasive technology for screening of individuals with risk of oral cancer // International scientific conference "Current problems of cellular of Biology and Biotechnology, October 11-13, 2015, Lviv, Ukraine.
2. Kireieva S., Yurchenko N., Sidorenko M., Pershko N. Association of cells expressing marker proteins of the epithelial stem/progenitor cells p63, Ck5/14, CD44 in the formation of the transformed phenotype in oral mucosa from patients with precancerous lesions and risk of oral cancer // International scientific conference "Current problems of cell biology and biotechnology, October 11-13, 2015, Lviv, Ukraine.
Scientific direction of research: the influence of factors of the cellular microenvironment on the development of the tumor population in monolayer and spheroid culture, the possibility of effective use of the model of multicellular tumor spheroids as a test model for the study of processes in tumor micrometastasis.
"Investigation of the composition of the population of stem tumor cells in the culture of tumor microspheroids" (Terms of execution: 2017-2021)
Publications:
1. Perepelitsina O.M., Yastrebova O.V., Yakymchuk O.M., Bezugliy S.V., Yurchenko N.P., Sydorenko M.V., Ostapchenko L.I. The effect of the cytosol of mesenchymal stem cells on the biochemical indicators of the blood of mice and the development of Ehrlich's adenocarcinoma // Buk. Med. Herald. - 2016. - Vol. 20, No. 4 (80). - P. 139-146.
2. Herheliuk T., Perepelytsina O., Sydorenko M., Yurchenko N., Ostapchenko L. Expression of tumor associated and epithelial-mesenchymal transition markers in 2D and 3D cell cultures of MCF-7 // EUREKA: Health Sciences. - 2016. - No. 6. - R. 37-44. DOI: 10.21303/2504-5679.2016. 00231.
3. Geregelyuk T., Perepelitsyna O., Yurchenko N., Yakymchuk O., Sydorenko M. Study of the kinetics of the development of Ehrlich's tumor after the introduction of cytosols of mesenchymal stem cells of the bone marrow of mice // Scientific conference "Theory and practice of modern morphology", 05-07.10 .2016, Dnipro, Ukraine.
4. Herheliuk T., Perepelytsina O., Sydorenko M., Yakymchuk O. Investigation of sensitivity of breast cancer cells to cellular origin biological agents and anticancer drugs in 2D and 3D cell culture // Ukrainian Congress of the Society of Cell Biology, 2- 6.10. 2016, Odesa, Ukraine.
5. Herheliuk T., Perepelytsina O., Sydorenko M., Yakymchuk O., Vdovichenko N. The study pro- and contra-oncogenic activity of the cellular origin biological agents // Ukrainian Congress of the Society of Cellular Biology, 2-6.10. 2016, Odesa, Ukraine.
6. Gergelyuk T.S., Yakymchuk O.M., Vdovichenko N.O., Perepelitsina O.M., Sydorenko M.V. The effect of mesenchymal stem cells on breast tumor cells in vivo and in vitro // Ukrainian Radiological Journal: Proceedings of the XIII Congress of Oncologists and Radiologists of Ukraine, Appendix 1, p. 193, 2016, Kyiv, Ukraine.
7. Gergelyuk T.S., Vdovichenko N.O., Yakymchuk O.M., Perepelitsina O.M., Sydorenko M.V. Study of the composition and sensitivity to the conditions of the microenvironment of the cell population of tumor microspheroids in vitro // Ukrainian Radiological Journal: Materials of the XIII Congress of Oncologists and Radiologists of Ukraine, Appendix 1, p. 193, 2016, Kyiv, Ukraine.
8. Yakymchuk O.M., Horodna O.V., Perepelitsina O.M., Sydorenko M.V., Bakalinska O.N. Testing of new antitumor compounds based on carbon nanomaterials and doxorubicin // Ukrainian Radiological Journal: Proceedings of the XIII Congress of Oncologists and Radiologists of Ukraine, Appendix 1, p. 163, 2016, Kyiv, Ukraine.
9. Perepelytsina O., Sydorenko M., Yakymchuk O., Rud A.D., Kirijan N.M., Bakalinska O. Implementation of innovation in medicine: why now? // EU-Eastern Partnership STI Cooperation in Addressing Health, Policy Stakeholders Conference in Budapest, 19-20 April 2016, Hungary.
10. Perepelitsyna E.M., Gergelyuk T.S., Sydorenko M.V.. Influence of T-lymphocytes and interferon-gamma on the stages of formation of multicellular tumor spheroids in vitro // Cytology and Genetics. - 2014. - Vol. 48, No. 5. - Page 18-25.
11. Zakordonets L., Dovbynchuk T., Putnikov A., Furzikova T., Perepelytsina O. et al. Effectiveness of multiprobiotic “Symbiter acidofilus” to prevent antibiotic-induced hepatic and colonic dysfunction // 3rd International Conference on Bioscience, Biochemistry and Bioinformatics – ICBBB 2013.
"Investigation of the influence of factors of cell origin on the population of stem tumor cells in the culture of tumor microspheroids". (Performance period 2017-2021)
Publications:
1. Herheliuk T., Perepelytsina O., Yakymchuk O., Ostapchenko L., Sydorenko M. The in vitro and in vivo effects of mesenchymal stem cells on breast cancer cells // Annals of Oncology 28 (suppl_1) 41P·May 20. DOI: 10.1093/annonc/mdx140.003.
"Determining the biosafety and cytotoxic effect of gold nanoparticles on monolayer and spheroid culture of tumor cells" of the fundamental topic "Biosafety and effectiveness of the interaction of inert metal nanoparticles with mesenchymal stem cells of the bone marrow" jointly with the IPKiK of the National Academy of Sciences of Ukraine" of the targeted comprehensive program of fundamental research "Fundamental problems of creating new nanomaterials and of nanotechnologies" of the National Academy of Sciences of Ukraine. (Performance period 2015-2019).
Publications:
1. Yakymchuk O.M., Perepelitsina O.M., Sydorenko M.V., Bakalinska O.M. Surface functionalization of carbon nanomaterials and attachment of doxorubicin // All-Ukrainian conference with international participation "Chemistry, physics and surface technology", May 13-15, 2015, Kyiv, Ukraine.
2. Fesenko O.M., Budnyk O.P., Volkova N.A., Pavlovich E.V., Perepelytsina O.M. SERS analysis and I oral cancer // International scientific conference "Current problems of cell biology and biotechnology, October 11-13, 2015, Lviv, Ukraine.
Scientific direction of research: the influence of factors of the cellular microenvironment on the development of the tumor population in monolayer and spheroid culture, the possibility of effective use of the model of multicellular tumor spheroids as a test model for the study of processes in tumor micrometastasis.
The proteome research group is studying changes in the expression profile of biomarker proteins p53 Ki-67, Bcl-2 and marker proteins of epithelial stem cells p63, Cк5/14, CD44, ALDH1, in the cell layers of the squamous epithelium of the oral mucosa during the formation of a transformed phenotype; epithelial-mesenchymal transition (EMT) in squamous cell carcinoma of the oral cavity during invasion and progression of the tumor process.
- Priority is to study the biology of cells that expressed marker proteins of the epithelial stem cells in formation of the transformed phenotype in oral mucosa of persons with cancer risk (smoking habits), precancerous lesions and progression of the oral squamous cell carcinoma.
Proteome research group studies changes in the profile of expression of biomarker proteins p53, Ki-67, Bcl-2 and marker proteins of epithelial stem cells p63, Ck5/14, CD44, ALDHI, in cell layers of the squamous epithelium of oral mucosa in the formation of the transformed phenotype; and epithelial-mesenchymal transition (EMT) in the oral squamous cell carcinoma (OSCC) in invasion and progression of the tumor process.
Projects implemented by the Laboratory:
"Investigation of the condition of the epithelium of the oral mucosa and the biology of basal cells during the formation of a transformed phenotype" (Performance period 2007 - 2011
Publications:
1. Kireeva S.S., Lisnyk I.O., Yurchenko N.P., Protsyk V.S., Sydorenko M.V. Expression of p53 and VEGF in oral cavity cancer patients // Journal of Ear, Nose and Throat Diseases. - 2008. - No. 4. - Page 52-57.
2. Borodai N.V., Sydorenko M.V., Yurchenko N.P., Datsyuk I.O. Densiometric parameters of the nuclei of cells of the mucous cavity and tumor cells in histological sections of biopsies of the epithelium at a distance from the tumor and the tumor in patients with cancer of the oral cavity // Journal of Ear, Nose and Throat Diseases. - 2008. - No. 4. - Page 6-10.
3. Kireeva S.S., Protsyk V.S., Yurchenko N.P., Osadcha O.M., Sydorenko M.V. Profile of proteins p53, Bsl-2, Ki-67 and changes in mucosal epithelium at a distance from the formed tumor in patients with oral cavity cancer // Journal of Ear, Nose and Throat Diseases. - 2010. - No. 4. - Page 57-59.
4. Kireeva S.S., Yurchenko N.P., Ishchenko V.V., Skrypnikova T.P., Bashtan V.P. p53 and Ki-67 as biomarkers for the objectification of histological diagnosis of precancerous conditions and cancer of the oral mucosa on biopsy material // Problems of ecology and medicine. - 2010. - Vol. 14, No. 3-4. - Pages 17-21.
5. Kireeva S.S., Lisnyak I.O., Yurchenko N.P., Protsyk V.S., Sydorenko M.V. Susceptibility of cultured lymphocytes to the mutagen bleomycin and the state of the mucosal epithelium at a distance from the formed tumor in patients with oral cavity cancer // Journal of Ear, Nose and Throat Diseases. - 2010. - No. 2. - Page 7-12.
6. Kireeva S.S., Yurchenko N.P., Ishchenko V.V., Protsyk V.S., Sydorenko M.V. Changes in the mucosa at a distance from the formed tumor and the profile of p53 and Ki-67 proteins in the cell layers of the mucosa epithelium in patients with squamous cell carcinoma of the oral cavity // Problems of ecology and medicine. - 2010. - Vol. 14, No. 3-4. - Page 17-21.
7. Kireeva S.S., Yurchenko N.P., Yakshibaeva Yu.R., Sydorenko M.V., Protsyk V.S. Study of the sensitivity of the body of a patient with oral cavity cancer to the mutagen bleomycin and the expression of p53 and the state of the mucous epithelium at a distance from the developed tumor // Proceedings of the VIII Congress of the Ukrainian Society of Geneticists and Breeders of Ukraine named after E. Vavilova - Kyiv, Logos, 2007. - p. 455-459.
8. Osadcha O., Kireeva S., Yurchenko N. Alterations in distant oral mucosa and buccal epithelium in patients with OSCC and with epidemiological risk // 118th European students conference. 7-11 October 2007, Berlin, Germany. Medical faculty of Humboldt University and Free University of Berlin. P. 300.
10. Kireeva S., Osadcha O., Sydorenko M. p53, Bcl-2, Ki-67 expression and alteration in tumor-distantoral mucosa in patients with oral squamous cell carcinoma (P34) // 5th international conference cancer prevention. Advances in molecular and clinical aspects of cancer prevention. 6-8 March 2008, St. Gallen, Switzerland // Europ. J. Cancer. - 2008. - vol. 6 (3). - P. 52.
11. Kireeva S., Yurchenko N., Sydorenko M., Protsyk V. P63, CK14 and p53 expression in epithelial layers of tumor-distant oral mucosa in patients with oral squamous cell carcinoma (P7) // 6-th international conference on clinical cancer prevention. 18-20 March 2010, St. Gallen, Switzerland // Europ. J. Cancer. - 2010. - vol. 8 (2). - P. 12.
12. Kireeva S. Mutagen sensitivity and p53 in suprabasal layers of tumor-distant oral mucosa in patients with oral squamous cell carcinoma (P6) // 6th international conference on clinical cancer prevention. 18-20 March 2010, St. Gallen, Switzerland // Europ. J. Cancer. - 2010. - vol. 8 (2). - P. 12.
13. Kireeva S.S. V.S. Protsyk Non-invasive impression technology for the objectification of cytological diagnosis of precancerous conditions, cancer of the oral cavity, screening and monitoring // Clinical Oncology. Special issue of the 12th Congress of Oncologists of Ukraine (meeting materials), September 20-22, 2011. Sudak, Autonomous Republic of Krym, p. 34.
14. Bashtan V.P., Kireeva S.S., Skrypnikov M.P., Skrypnikova T.P., Ivashchenko V.V. Improving the efficiency of early diagnosis of precancerous conditions of the oral mucosa by the method of evaluating the expression of biomarker proteins p53 and Ki-67 // Clinical Oncology. Special issue of the 12th Congress of Oncologists of Ukraine (meeting materials), September 20-22, 2011. Sudak, Autonomous Republic of Krym, p. 27.
"Study of the expression of marker proteins of epithelial stem and progenitor cells in oral cavity cancer" (Performance period: 2012-2014
Publications:
1. N.V. Boroday, D.A. Klyushiv, Y.A. Petunin, O. Lyakhovka, F. Miropolsku, R.A. Andrushkiv. Retrospective cohort investigation of risk factors in breast cancer. METMBS " 04- Las Vegas, Nevada, 2004, 385-390.
2. S. Kirieieva, N. Yurchenko, V. Shukalevych, Yu. Yakshibayeva, M. Sidorenko, V. Protsyk. Serial cytological assay of buccal exfoliated cells as technology for mass screening of individuals at risk of oral cancer for monitoring and cancer prevention // Europ. J. Cancer. - 2006; 4 (1): 52-54.
3. N. Boroday, D. Klyushin, Y. Petunin, R. Andrushkiv. Analysis of malignancy-associated DNA changes in interphase nuclei of buccal epithelium with breast diseases // Experimental Oncology - 2004; 26 (2): 158-160.
4. S.S. Kireeva, O.I. Dasyukevich, D. P. Burlaka, V. B. Vynnytskyi. Peculiarities of hormonal and genetic homeostasis in men with gynecomastia and breast cancer // Bukovynsky Medical Bulletin. -.2002. - vol. 6 (1). - Page 55-59.
5. S.S. Kireeva, M.V. Sydorenko Cytogenetic changes in bone marrow cells of mice with different genotypes under the influence of therapeutic doses of cyclophosphane and cisplatin // Bukovynskyi medical bulletin. - 2006. - v. 10 (3). - Page 105-110.
6. S.S. Kireeva, N.P. Yurchenko, M.V. Sydorenko, N.Yu. Pershko, V.S. Protsik
"Expression of marker proteins of epithelial stem and progenitor cells: regulatory nuclear protein p63 and cytokeratins SK5/14 in the epithelium of the mucous membrane of the oral cavity in precancerous conditions // Journal of Ear, Nose and Throat Diseases. - 2014. - No. 1. - Page 8-16.
7. Kirieieva S., Yurchenko N., Sidorenko M., Pershko N. Suprabasal expression oh the marker proteins of the epithelial stem and progenitor cells p63, CD44 in precancerous lesions and oral mucosa from patients with risk of oral cancer // Collection of scientific Proceedings - International symposium on cell biology jointly with 4-th Ukrainian congress for cell biology. - September 17-20, 2014, Uzhhorod, Ukraine.
8. Yurchenko N.P., Kirieieva S.S., Sidorenko M.V., Pershko N.Yu., Protsyk V. Expression of marker proteins of the epithelial stem/progenitor cells p63, CK5/14 in oral mucosa from patients with precancerous lesions and oral cancer // Ukr . biochem. journal - 2014. - Vol. 86, No. 5 (Part 1). - Collection of scientific papers. - XI Ukrainian Biochemical Congress. - November 6-10, 2014, Kyiv, Ukraine.
9. Yurchenko N.P., Kireeva S.S., Sydorenko M.V., Pershko N.Yu., Protsyk V.S. "Changes in the mucous membrane of the oral cavity at a distance from the formed tumor in patients with squamous cell cancer and in persons from the risk group" // Rhinology. - 2013. - No. 2. - p. 35-40.
10. Pershko N., Levchenko O., Fedorenko O., Sidorenko M. Researching albumin-calcium complexes in blood with malignant tumors as a possible markers of oncopathology // 7th Lviv-Lublin Conference on Experimental and Clinical Biochemistry, 23 - May 24, 2013, Lviv, Ukraine.
11. Kokutsa R.V., Yurchenko N.P., Kireeva S.S. Assessment of changes in the mucous membrane of the oral cavity in persons at risk of cancer to monitor the effectiveness of preventive therapy in the conditions of polyclinic dental examination and treatment.// Proceedings of the International scientific and practical conference "Perspectives for the development of staged restorative treatment". - 03.2012.
"Investigate the epithelial-mesenchymal transition and its connection with tumor cells that express marker proteins of epithelial stem cells in oral cancer" (Performance period: 2012-2014)
Publications:
1. Yurchenko N., Kireieva S., Sidorenko M., Pershko N., Protsyk V., Boychuk A., Korolchuk O. The noninvasive technology for screening of individuals with risk of oral cancer // International scientific conference "Current problems of cellular of Biology and Biotechnology, October 11-13, 2015, Lviv, Ukraine.
2. Kireieva S., Yurchenko N., Sidorenko M., Pershko N. Association of cells expressing marker proteins of the epithelial stem/progenitor cells p63, Ck5/14, CD44 in the formation of the transformed phenotype in oral mucosa from patients with precancerous lesions and risk of oral cancer // International scientific conference "Current problems of cell biology and biotechnology, October 11-13, 2015, Lviv, Ukraine.
Scientific direction of research: the influence of factors of the cellular microenvironment on the development of the tumor population in monolayer and spheroid culture, the possibility of effective use of the model of multicellular tumor spheroids as a test model for the study of processes in tumor micrometastasis.
"Investigation of the composition of the population of stem tumor cells in the culture of tumor microspheroids" (Terms of execution: 2017-2021)
Publications:
1. Perepelitsina O.M., Yastrebova O.V., Yakymchuk O.M., Bezugliy S.V., Yurchenko N.P., Sydorenko M.V., Ostapchenko L.I. The effect of the cytosol of mesenchymal stem cells on the biochemical indicators of the blood of mice and the development of Ehrlich's adenocarcinoma // Buk. Med. Herald. - 2016. - Vol. 20, No. 4 (80). - P. 139-146.
2. Herheliuk T., Perepelytsina O., Sydorenko M., Yurchenko N., Ostapchenko L. Expression of tumor associated and epithelial-mesenchymal transition markers in 2D and 3D cell cultures of MCF-7 // EUREKA: Health Sciences. - 2016. - No. 6. - R. 37-44. DOI: 10.21303/2504-5679.2016. 00231.
3. Geregelyuk T., Perepelitsyna O., Yurchenko N., Yakymchuk O., Sydorenko M. Study of the kinetics of the development of Ehrlich's tumor after the introduction of cytosols of mesenchymal stem cells of the bone marrow of mice // Scientific conference "Theory and practice of modern morphology", 05-07.10 .2016, Dnipro, Ukraine.
4. Herheliuk T., Perepelytsina O., Sydorenko M., Yakymchuk O. Investigation of sensitivity of breast cancer cells to cellular origin biological agents and anticancer drugs in 2D and 3D cell culture // Ukrainian Congress of the Society of Cell Biology, 2- 6.10. 2016, Odesa, Ukraine.
5. Herheliuk T., Perepelytsina O., Sydorenko M., Yakymchuk O., Vdovichenko N. The study pro- and contra-oncogenic activity of the cellular origin biological agents // Ukrainian Congress of the Society of Cellular Biology, 2-6.10. 2016, Odesa, Ukraine.
6. Gergelyuk T.S., Yakymchuk O.M., Vdovichenko N.O., Perepelitsina O.M., Sydorenko M.V. The effect of mesenchymal stem cells on breast tumor cells in vivo and in vitro // Ukrainian Radiological Journal: Proceedings of the XIII Congress of Oncologists and Radiologists of Ukraine, Appendix 1, p. 193, 2016, Kyiv, Ukraine.
7. Gergelyuk T.S., Vdovichenko N.O., Yakymchuk O.M., Perepelitsina O.M., Sydorenko M.V. Study of the composition and sensitivity to the conditions of the microenvironment of the cell population of tumor microspheroids in vitro // Ukrainian Radiological Journal: Materials of the XIII Congress of Oncologists and Radiologists of Ukraine, Appendix 1, p. 193, 2016, Kyiv, Ukraine.
8. Yakymchuk O.M., Horodna O.V., Perepelitsina O.M., Sydorenko M.V., Bakalinska O.N. Testing of new antitumor compounds based on carbon nanomaterials and doxorubicin // Ukrainian Radiological Journal: Proceedings of the XIII Congress of Oncologists and Radiologists of Ukraine, Appendix 1, p. 163, 2016, Kyiv, Ukraine.
9. Perepelytsina O., Sydorenko M., Yakymchuk O., Rud A.D., Kirijan N.M., Bakalinska O. Implementation of innovation in medicine: why now? // EU-Eastern Partnership STI Cooperation in Addressing Health, Policy Stakeholders Conference in Budapest, 19-20 April 2016, Hungary.
10. Perepelitsyna E.M., Gergelyuk T.S., Sydorenko M.V.. Influence of T-lymphocytes and interferon-gamma on the stages of formation of multicellular tumor spheroids in vitro // Cytology and Genetics. - 2014. - Vol. 48, No. 5. - Page 18-25.
11. Zakordonets L., Dovbynchuk T., Putnikov A., Furzikova T., Perepelytsina O. et al. Effectiveness of multiprobiotic “Symbiter acidofilus” to prevent antibiotic-induced hepatic and colonic dysfunction // 3rd International Conference on Bioscience, Biochemistry and Bioinformatics – ICBBB 2013.
"Investigation of the influence of factors of cell origin on the population of stem tumor cells in the culture of tumor microspheroids". (Performance period 2017-2021)
Publications:
1. Herheliuk T., Perepelytsina O., Yakymchuk O., Ostapchenko L., Sydorenko M. The in vitro and in vivo effects of mesenchymal stem cells on breast cancer cells // Annals of Oncology 28 (suppl_1) 41P·May 20. DOI: 10.1093/annonc/mdx140.003.
"Determining the biosafety and cytotoxic effect of gold nanoparticles on monolayer and spheroid culture of tumor cells" of the fundamental topic "Biosafety and effectiveness of the interaction of inert metal nanoparticles with mesenchymal stem cells of the bone marrow" jointly with the IPKiK of the National Academy of Sciences of Ukraine" of the targeted comprehensive program of fundamental research "Fundamental problems of creating new nanomaterials and of nanotechnologies" of the National Academy of Sciences of Ukraine. (Performance period 2015-2019).
Publications:
1. Yakymchuk O.M., Perepelitsina O.M., Sydorenko M.V., Bakalinska O.M. Surface functionalization of carbon nanomaterials and attachment of doxorubicin // All-Ukrainian conference with international participation "Chemistry, physics and surface technology", May 13-15, 2015, Kyiv, Ukraine.
2. Fesenko O.M., Budnyk O.P., Volkova N.A., Pavlovich E.V., Perepelytsina O.M. SERS analysis and I oral cancer // International scientific conference "Current problems of cell biology and biotechnology, October 11-13, 2015, Lviv, Ukraine.
Scientific direction of research: the influence of factors of the cellular microenvironment on the development of the tumor population in monolayer and spheroid culture, the possibility of effective use of the model of multicellular tumor spheroids as a test model for the study of processes in tumor micrometastasis.
Development of a cellular test system for determining the effectiveness and mechanisms of action of anticancer drugs
Determination of the biosafety and cytotoxic effect of gold nanoparticles on monolayer and spheroid culture of tumor cells
Study of the effect of metal-containing and carbon nanomaterials as a matrix on cell growth in vitro
Study of the effect of metal-containing and carbon nanomaterials as a matrix on cell growth in vitro
