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Scientific direction: the study of the phenomenon of ultra-fast freezing of biological objects of various degrees of complexity with the development of recipes and freezing protocols for each level of biological structures.
Projects implemented by the Laboratory:
Study of the phenomenon of ultra-fast cooling of biological objects for the creation of a device for cryopreservation" (Performance period: 2013-2016)
Publications:
1. Perepelytsina O., Ugnivenko A., Burlaka D., Bezugly S., Sydorenko M. Optimization of human somatic cells cryopreservation protocols by polyethylene glycols // Medical and clinical chemistry. - 2016. - Vol. 18, No. 3. - P. 5-12.
2. Utility model patent "Method of cryopreservation of somatic cells" No. 117693, u201612432, published on July 10, 2017.
3. Utility model patent "Medium for cryopreservation of somatic cells" No. 117694, u201612433, published on July 10, 2017.
"The phenomenon of ultra-fast cooling of biological objects: development of efficient freezing protocols". (Performance period 2017-2021)
"Investigation of the effect of metal-containing and carbon nanomaterials as a pro-differentiation matrix during cell growth in vitro" of the target complex program of fundamental research "Fundamental problems of nanostructural systems, nanomaterials, nanotechnologies" of the National Academy of Sciences of Ukraine. (2010-2014).
Publications:
1. Yakymchuk O.M., Perepelytsina O.M., Rud A.D., Kirian I.M., Sydorenko M.V. Impact of carbon nanomaterials on the formation of multicellular spheroids by tumor cells // Physica status solidi. - 2014. - P. 1-7 / DOI 10.1002/psssa.201431358.
2. Yakymchuk O.M., Perepelytsina O.M., Rud A.D., Kirian I.M., Beliy N.M., Sydorenko M.V. Ultrafine dispersed nanodiamonds: effect on molecular processes in the cell // Proceedings of E-MRS 2014 Spring Meeting? 26-30.05.2014, Lille, France.
3. Perepelytsina O.M., Sydorenko M.V., Demianenko D.P., Rud A.D., Kirian I.M. Influence of carbon nanomaterials on 3D culture of tumor cells // Collection of scientific papers - International scientific and practical conference: Nanotechnology and nanomaterials, 17-30.08.2014, Lviv, Ukraine.
4. O.M. Yakymchuk, O.M. Perepelitsyna, M.V. Sydorenko, D.P. Demyanenko, A.D. Rud, I.M. Kiriyan, and M.N. White. Ultradisperse diamonds: influence on molecular processes in tumor cells // Collection of scientific papers - International scientific and practical conference: Nanotechnology and nanomaterials, 17-30.08.2014, Lviv, Ukraine.
5. Perepelytsina O.M., A.D. Rud, Gergeliuk T.S., Biliy M.M., Sydorenko M.V., Kiryan I.M. Biochemical and cytotoxic properties of ultra dispersed diamonds // Collection of Scientific Articles "Carbon Particles in Condensed Media" of the VII International Conference "Fullerenes and Nanostructures in Condensed Media", Minsk, Belarus, June 9-12, 2013 - pp. 334-339 .
6. E.M. Perepelytsina, M.V. Sidorenko, D.P. Demianenko, A.D. Rud, N.M. Beliy. The study of influence of ultrafine nanodiamonds on tumor cell population in vitro // International scientific and practical conference: Nanotechnology and nanomaterials, 29.08-1.09.2013, Bukovel, Ukraine
7. E.M. Perepelitsyna, A.D. Rud, E.M. Yakymchuk, I.M. Kiryan, N.M. Bely, M.V. Sydorenko. Investigating the possibility of using nanomaterials as an extracellular matrix // IV International Scientific Conference "Nano-sized systems: structure, properties, technologies" - 2013.
Projects implemented by the Laboratory:
Study of the phenomenon of ultra-fast cooling of biological objects for the creation of a device for cryopreservation" (Performance period: 2013-2016)
Publications:
1. Perepelytsina O., Ugnivenko A., Burlaka D., Bezugly S., Sydorenko M. Optimization of human somatic cells cryopreservation protocols by polyethylene glycols // Medical and clinical chemistry. - 2016. - Vol. 18, No. 3. - P. 5-12.
2. Utility model patent "Method of cryopreservation of somatic cells" No. 117693, u201612432, published on July 10, 2017.
3. Utility model patent "Medium for cryopreservation of somatic cells" No. 117694, u201612433, published on July 10, 2017.
"The phenomenon of ultra-fast cooling of biological objects: development of efficient freezing protocols". (Performance period 2017-2021)
"Investigation of the effect of metal-containing and carbon nanomaterials as a pro-differentiation matrix during cell growth in vitro" of the target complex program of fundamental research "Fundamental problems of nanostructural systems, nanomaterials, nanotechnologies" of the National Academy of Sciences of Ukraine. (2010-2014).
Publications:
1. Yakymchuk O.M., Perepelytsina O.M., Rud A.D., Kirian I.M., Sydorenko M.V. Impact of carbon nanomaterials on the formation of multicellular spheroids by tumor cells // Physica status solidi. - 2014. - P. 1-7 / DOI 10.1002/psssa.201431358.
2. Yakymchuk O.M., Perepelytsina O.M., Rud A.D., Kirian I.M., Beliy N.M., Sydorenko M.V. Ultrafine dispersed nanodiamonds: effect on molecular processes in the cell // Proceedings of E-MRS 2014 Spring Meeting? 26-30.05.2014, Lille, France.
3. Perepelytsina O.M., Sydorenko M.V., Demianenko D.P., Rud A.D., Kirian I.M. Influence of carbon nanomaterials on 3D culture of tumor cells // Collection of scientific papers - International scientific and practical conference: Nanotechnology and nanomaterials, 17-30.08.2014, Lviv, Ukraine.
4. O.M. Yakymchuk, O.M. Perepelitsyna, M.V. Sydorenko, D.P. Demyanenko, A.D. Rud, I.M. Kiriyan, and M.N. White. Ultradisperse diamonds: influence on molecular processes in tumor cells // Collection of scientific papers - International scientific and practical conference: Nanotechnology and nanomaterials, 17-30.08.2014, Lviv, Ukraine.
5. Perepelytsina O.M., A.D. Rud, Gergeliuk T.S., Biliy M.M., Sydorenko M.V., Kiryan I.M. Biochemical and cytotoxic properties of ultra dispersed diamonds // Collection of Scientific Articles "Carbon Particles in Condensed Media" of the VII International Conference "Fullerenes and Nanostructures in Condensed Media", Minsk, Belarus, June 9-12, 2013 - pp. 334-339 .
6. E.M. Perepelytsina, M.V. Sidorenko, D.P. Demianenko, A.D. Rud, N.M. Beliy. The study of influence of ultrafine nanodiamonds on tumor cell population in vitro // International scientific and practical conference: Nanotechnology and nanomaterials, 29.08-1.09.2013, Bukovel, Ukraine
7. E.M. Perepelitsyna, A.D. Rud, E.M. Yakymchuk, I.M. Kiryan, N.M. Bely, M.V. Sydorenko. Investigating the possibility of using nanomaterials as an extracellular matrix // IV International Scientific Conference "Nano-sized systems: structure, properties, technologies" - 2013.
Development of a cellular test system for determining the effectiveness and mechanisms of action of anticancer drugs
Determination of the biosafety and cytotoxic effect of gold nanoparticles on monolayer and spheroid culture of tumor cells
Study of the effect of metal-containing and carbon nanomaterials as a matrix on cell growth in vitro
Study of pro- and anti-oncogenic activity of biological substances of cellular origin
