News
Contacts
Advertisement
Laboratories
Scientific direction of research: modeling and study of the processes of formation of avascular tumor aggregates, interaction of tumor cells and elements of the immune system and stroma, increasing the effectiveness of antitumor therapy due to the modulation of the conditions of the tumor microenvironment.
- modeling and studying the formation of avascular tumor aggregates, the interaction of tumor cells and elements of the immune system and stroma, increasing the effectiveness of antitumor therapy by modulating the conditions of the tumor microenvironment.
Projects implemented by the Laboratory:
"Investigation of the possibilities of directed influence on the morphogenesis of cell spheroids in vitro." (Performance period 2008-2011
Publications:
1. Perepelitsina O.M., Garmanchuk L.V., Sydorenko M.V. Multicellular spheroids of breast cancer cells: conditions of generation of MCF-7 and the influence of serum factors // Bukovynskyi medical bulletin.- 2007.- T.11, No. 3.- C.128-133.
2. Kokozei V.M., Garmanchuk L.V., Nestorova O.V., Yavorska N.V., Senchylo N.V., Pozur V.V. Utility model patent "Use of copper and cadmium acetate complex with ethylenediamine as an antitumor and anti-metastatic agent" No. 36261 dated 10/27/2008.
3. Perepelitsina O.M., Garmanchuk L.V., Sydorenko M.V. Utility model patent "Method of testing biologically active compounds for their suitability as medicinal products" No. 35037, dated 08.26.08.
4. Perepelitsina O.M., Garmanchuk L.V., Kobelska O.S., Sydorenko M.V. Influence of humoral factors produced by T-lymphocytes on the proliferation and survival of MCF-7 cells // Immunology and Allergology. - 2008. - No. 2. - P.88-90.
5. Perepelitsyna O.M., Garmanchouk L.V., Sydorenko M.V., Ostapchenko L.I. Reactivity and sensitivity of breast adenocarcinoma (MCF-7) in coculture depends on architecture of cells model // Physics of the Alive. - 2008. – vol. 16, No. 2. - P. 105-111.
6. Harmanchuk L.V., Perepelitsna E.M., Sydorenko M.V., Makarenko A.N., Kulchikov A.E. Cytoprotective effect of neuropeptides on immunocompetent cells (in vitro research) // Experimental and clinical pharmacology. - 2009. - vol. 79. - p. 28-31.
7. Garmanchuk L.V., Perepelitsyna O.M., Sydorenko M.V., Ostapchenko L.I. Growth kinetics of 2- and 3-D cell models as influenced by microenvironment // Cytology and genetics. - 2009. - No. 5. - R. 305-309.
8. Kulchikov A.E., Molozavaya O.S., Skachkova O.V., Garmanchuk L.V., Sydorenko M.V., Perepelitsyna E.M., Khranovskaya N.N., Makarenko A.N. Comparative study of the immunocorrective action of neuropeptide drugs in acute cerebrovascular pathology // Cytokines and inflammation. - 2009. - No. 3. - Pages 18-23.
9. Garmanchuk L.V., Perepelitsyna O.M., Sydorenko M.V., Ostapchenko L.I. Formation of multicellular aggregates under different conditions of microenvironment // Cytology and genetics. - 2010. - vol. 44, No. 1. - R. 19-22.
10. Perepelitsina O.M., Harmanchuk L.V., Shevchenko E.A., Sydorenko M.V., Ostapchenko L.I. Comparison of the level of NO production and the proliferation of MCF-7 breast cancer cells during modification of the microenvironment // Ukr. biochemical journal. - 2010. - Vol. 82, No. 4. - P. 60-68.
11. Nepiyvoda H.D., Garmanchuk L.V., Perepelitsina O.M., Skachkova O.V., Khranovska N.M., Sydorenko M.V., Ostapchenko L.I. Survival of 3-D culture of MCF-7 cells in a serum-free environment // Reports of the National Academy of Sciences of Ukraine. – 2011. - No. 8. - P. 160-164.
12. Harmanchuk L.V., Khranovskaya N.N., Makarenko A.N., Mazur O.V., Skachkova O.V., Nepiyvoda H.D., Lavrova E.V., Perepelitsyna E.M., Senchylo N.V., Vasilyeva I.G., Ostapchenko L.I. Complex study of the immunomodulating influence of drugs with a nootropic mechanism of action on immunocompetent cells // Journal. National Academy of Sciences of Ukraine. - 2011. - 17, No. 3. - P. 218-226.
11. Perepelitsyna O.M., Garmanchouk L.V., Sydorenko M.V. Indirect influence of co-cultures MT4 on multicellular spheroids of breast adenocarcinoma (MCF7) // UICC, World-cancer congress, 31 August 2008, Geneva, Switzerland. [POS-B146].
12. Perepelitsyna E.M., Harmanchuk L.V., Kobelskaya E.S., Sydorenko M.V. Multidirectional influence of K-environment of tumor lymphocytes on the proliferative activity of MSC-7 cells growing in 2-D and 3-D cultures // New cryobiotechnologies for solving fundamental and applied problems of medicine, November 26-28, 2008, Kharkiv, Ukraine.
13. Harmanchuk L.V. Perepelitsyna E.M., Sydorenko M.V., Makarenko A.N., Kulchikov A.E. Comparative study of the effect of neuroprotectors on T-lymphocytes // Materials of the XVI Russian National Congress "Man and Medicine", April 6-10, 2009, Moscow, Russia.
14. Harmanchuk L.V., Perepelitsyna E.M., Sydorenko M.V., Makarenko A.N., Kulchikov A.E. Comparative study of the action of neuroprotectors on B-lymphocytes // Materials of the XVI Russian National Congress "Man and Medicine", April 6-10, 2009, Moscow, Russia.
15. Harmanchuk L.V., Perepelitsyna E.M., Nepiyvoda K.D., Ostapchenko L.I., Sydorenko M.V. Autocrine production of EGFR-like polypeptides by tumor cells as a factor in their progression //Biologically active substances, fundamental and applied issues of production and use, May 25, 2009, New World, Crimea, Ukraine. - Page 285-286.
16. Perepelitsyna O.M., Shevchenko E.A., Skopenko O.V., Garmanchuk L.V., Aleksieva I.V., Palchikovska L.G., Sidorenko M.V. 6-azacytidine xylofuranoside inhibits the production of nitric oxide by plump cells MCF-7 // Biologically active substances, fundamental and applied issues of production and application, May 25, 2009, New World, Crimea, Ukraine. - Page. 379-380.
17. Yavorskaya N.V., Garmanchuk L.V., Perepelitsyna E.M., Senchilo N.V., Furzikova T.M., Nesterova O.V., Kokozey V.N., Pozur V.K. Bactericidal, fungicidal and cytotoxic effects of heterobimetallic complexes // Biologically active substances, fundamental and applied issues of production and application, May 25, 2009, New World, Crimea, Ukraine. - Page. 451-452.
18. Perepelytsina O.M., Garmanchouk L.V., Sidorenko M.V., Kobelska O.S., Spivak N.J., Makarenko A.N. Immunotherapy and development of the cultural breast cancer // Annals of Oncology. - 2009. - vol. 20, no. 2. – P.85.
19. Garmanchuk L.V., Perepelitsyna E.M., Sidorenko M.V., Makarenko A.N., Kulchikov A.E. Cytoprotective effect of neuropeptides on immunocompetent cells (in vitro study) // Experimental and clinical pharmacology. - 2009. – 79, No. 4. – pp. 28-32.
20. Kobelska O.S., Zholobak N.M., Olenivska Z.M., Perepelitsina O.M., Maltsev G.V., Lyakhov S.A., Andronati S.A., Spivak M.Ya. Investigation of the toxicity and interferonogenic activity of biphenyl-like substances in the culture of MT-4 cells // XII Meeting of the Association of Microbiologists of Ukraine named after S.M. Vinogradsky, grass 2009. - P. 192.
21. Perepelytsina O., Garmanchouk L., Sydorenko M., Ostapchenko L.I. Role of paracrine influence of T-lymphocytes in the regulation of the breast carcinogenesis on model of multicellular tumor spheroids // Breast Cancer Conference, March 2011, St.-Gallen, Switzerland.
22. Perepelytsina O., Garmanchouk L., Sydorenko M., Gergeliuk T. Estrogen abrogated cytotoxic effect of tamoxifen on MCF-7 after activation of estrogen receptor by T-cells // ESMO-IMPAKT conference, May 2011, Brussels, Belgium.
t. Perepelytsina O., Sydorenko M., Skachkova O., Gergeliuk T. Methods for increasing titer of IFN in the body influencing the effectiveness of hormonal therapy of breast cancer // Biologycally active substances: fundamental and applied problems, May 2011, Kiev Ukraine.
23. Garmanchuk L.V., Cheshuk V.E., Perepelitsina E.M., Sydorenko M.V. EGFR exspression and dimerization in the breast cancer resected postoperative tissue can be negative prognostic factor // Primary therapy of early breast cancer/The Breast: 11th internat. conference., 11-14 March 2009.: abstract book.- St. Galen, Switzerlald, 2009. - [0042].-S.28.
“Investigation of the anti-oncogenic activity of biological proteins of the cell gait.” (Term of Vikonanny 2011-2015)
Publications:
1. Indirect influence of co-cultures MT4 on multicellular spheroids of breast adenocarcinoma (MCF7); UICC, World-cancer congress, 31 August, 2008, Geneva [POS-B146]; Perepelitsyna O.M., Garmanchouk L.V., Sydorenko M.V.
2. Reactivity and sensibility of breast adenocarcinoma (MCF-7) in coculture depends on architecture of cells model; Physics of the Alive, v.16, No.2, 2008; Perepelitsyna O.M., Garmanchouk L.V., Sydorenko M.V., Ostapchenko L.I.
3. EGFR expression and dimerization in the breast cancer resected postoperative tissue can be a negative prognostic factor; THE BREAST, Volume 18, Supplement 1, March 2009, P S28; Garmanchouk L.V., O.M.Perepelytsina, V.E. Cheshuk, M.V. Sydorenko.
4. Growth Kinetics of 2- and 3-D Cell Models as Influenced by the Microenvironment; Cytology and genetics, 2009, Vol.43, No.5, P 305-309; L.V. Garmanchouk, O.M. Perepelytsina, M.V. Sidorenko, L.I. Ostapchenko.
5. Formation of Multicellular Aggregates under Different conditions of microenvironment; Cytology and genetics.- 2010.- Vol.44, No. 1.- P. 19-22; Perepelitsyna O.M., Garmanchouk L.V., Sydorenko M.V., Ostapchenko L.I.
6. Role of paracrine influence of T-lymphocytes in the regulation of the breast carcinogenesis on model of multicellular tumor spheroids; St. Gallen Breast Cancer Conference, March, 2011; Abstract, poster presentation; Perepelytsina O., Garmanchouk L., Sydorenko M., Ostapchenko L.I.
7. Estrogen abrogated cytotoxic effect of tamoxifen on MCF-7 after activation of estrogen receptor by T-cells; ESMO-IMPAKT conference, Brussels, May, 2011. Grand Susan G Commen for cure; Abstract, poster presentation; Perepelytsina O., Garmanchouk L., Sydorenko M., Gergeliuk T.
8. Perepelitsyna O. M., Gergelyuk T. S., Demianenko D., Goncharuk O., Golstev A., Sydorenko M. V. The receptor profile of breast tumor cells and formation of spheroids under influence of MSC // In this supplement primary therapy of early breast cancer 13 TH international conference st. Gallen, Switzerland, 13-16 March 2013.
9. Perepelitsyna O. M., Gergelyuk T. S., Demianenko D., Sydorenko M. V. Formation of multicellular tumor spheroids by MCF-7 and sensitivities to anticancer therapy // In this supplement primary therapy of early breast cancer 13-th international conference St. Gallen, Switzerland, March 13-16, 2013.
10. T.S. Gergelyuk, O.M. Perepelitsina, M.V. Sydorenko Comparison of the effects of conditioned medium from human mesenchymal stem cells and interferon-A on the development of the MCF-7 tumor cell population // Bukovynsky medical bulletin. - 2014. - No. 2 (70). - Page 18-23.
11. Demianenko D., Perepelytsina O., Yastrebova O., Sydprenko M. Effect of IFN-alpha and IFN-gamma on proliferation and receptor profile line of breast and colon cancer cells // Collection of scientific papers - International symposium on cell biology jointly with the 4th Ukrainian congress for cell biology. - September 17-20, 2014, Uzhhorod, Ukraine.
"Development of a cellular test system for evaluating the effectiveness and mechanisms of action of anticancer drugs" (Performance term 2016-2020
Publications:
1. Perepelytsina O.M., Yakymchuk O., Vdovichenko N., Sydorenko M.V., Bakalinska O.N. Tumor spheroids as a model for testing new anticancer drugs and not only // Enabling technologies in 3D cancer organoids, March 8-9, 2016, Torino, Italy.
2. Herheliuk T., Perepelytsina O., Ostapchenko L., Yakymchuk O., Sydorenko M. Comparison of biological properties of C-medium from mesenchymal stem cells on 2D and 3D cells cultures of MCF-7 // Collection of theses of the XII International Scientific conference of students and postgraduates "Youth and the progress of biology" - Lviv, April 25-27, 2017, Ukraine. - p. 243.
"Testing of a carbon-protein construct for the targeted delivery of anticancer drugs" of the targeted complex interdisciplinary program of scientific research of the National Academy of Sciences of Ukraine "Molecular and cellular biotechnologies for the needs of medicine, industry and agriculture" and the order of the Presidium of the National Academy of Sciences of Ukraine dated 04.17.15 No. 289. (Execution period 2015 -2019).
Publications:
1. Perepelytsina O.M., Yakymchuk O.M., Sydorenko M.V., Bakalinska O.N., Blosi F., Califano V., Vicari L.R.M. Functionalisation of carbon nanomaterials surface by doxorubicin and antibodies to tumor markers // European Materials Research Society, 2015 Spring meeting, 11-15 May 2015, Lille Grand Palais, France.
2. Perepelytsina O.M., Yakymchuk O.M., Sydorenko M.V., Bakalinska O.N., Blosi F., Califano V., Vicari L.R.M. Impact of functionalized carbon nanomaterials on human tumor cells // III International research and practical conference "Nanochemistry and biotechnology" of International research and practice conference "Nanotechnology and nanomaterials", 26-29.08.2015. Lviv., Ukraine.
3. Perepelytsina O.M., Yakymchuk O.M., Sydorenko M.V., Bakalinska O.N. Functionalization of carbon nanomaterials surface by Doxorubicin and antibodies to tumor markers // Nanoscale Research Letters. - 2016. - 11(1):314. DOI: 10.1186/s11671-016-1537-z.
4. Ugnivenko A.P., Perepelitsina O.M., Sydorenko M.V., Ostapchenko L.I. Carbon nanotubes in delivery of bioactive substances // J. Bionanoscience. - 2017. - Vol. 11, No. 6 (17). - P. 531-547. doi.org/10.1166/jbns.2017.1475
5. Nesterenko O.M., Herheliuk T.S., Perepelytsina O.M., Sydorenko M.V., Bakalinska O.M., Ostapchenko L.I. Investigation of the degree of binding and controlled release of doxorubicin from the UDD and OLC // Proceedings of Ukrainian Conference with Internetional participationn "Chemistry, physics and technology of surface" and Workshop "Nanostructured biocompatible/bioactive material". - P. 112. 24-25 May, 2017. Kyiv, Ukraine.
6. Goncharuk O.V., Ugnivenko A.P., Terpilowski K., Skwarek E., Gun'ko V.M. Effect of ethonium adsorption on structure formation in nanosilica dispersions // // Proceedings of Ukrainian Conference with Internetional participationn "Chemistry, physics and technology of surface" and Workshop "Nanostructured biocompatible/bioactive material". - P. 66. 24-25 May, 2017. Kyiv, Ukraine.
7. Nesterenko O.M., Herheliuk T.S., Perepelytsina O.M., Sydorenko M.V., Bakalinska O.M., Ostapchenko L.I. Investigation of the effectiveness of carbon nanotubes for targeted delivery of antitumor drugs, International research and practice conference: Nanotechnology and Nanomaterials (NANO-2017), August 23-26, 2017, p. 636, Chernivtsi, Ukraine.
- modeling and studying the formation of avascular tumor aggregates, the interaction of tumor cells and elements of the immune system and stroma, increasing the effectiveness of antitumor therapy by modulating the conditions of the tumor microenvironment.
Projects implemented by the Laboratory:
"Investigation of the possibilities of directed influence on the morphogenesis of cell spheroids in vitro." (Performance period 2008-2011
Publications:
1. Perepelitsina O.M., Garmanchuk L.V., Sydorenko M.V. Multicellular spheroids of breast cancer cells: conditions of generation of MCF-7 and the influence of serum factors // Bukovynskyi medical bulletin.- 2007.- T.11, No. 3.- C.128-133.
2. Kokozei V.M., Garmanchuk L.V., Nestorova O.V., Yavorska N.V., Senchylo N.V., Pozur V.V. Utility model patent "Use of copper and cadmium acetate complex with ethylenediamine as an antitumor and anti-metastatic agent" No. 36261 dated 10/27/2008.
3. Perepelitsina O.M., Garmanchuk L.V., Sydorenko M.V. Utility model patent "Method of testing biologically active compounds for their suitability as medicinal products" No. 35037, dated 08.26.08.
4. Perepelitsina O.M., Garmanchuk L.V., Kobelska O.S., Sydorenko M.V. Influence of humoral factors produced by T-lymphocytes on the proliferation and survival of MCF-7 cells // Immunology and Allergology. - 2008. - No. 2. - P.88-90.
5. Perepelitsyna O.M., Garmanchouk L.V., Sydorenko M.V., Ostapchenko L.I. Reactivity and sensitivity of breast adenocarcinoma (MCF-7) in coculture depends on architecture of cells model // Physics of the Alive. - 2008. – vol. 16, No. 2. - P. 105-111.
6. Harmanchuk L.V., Perepelitsna E.M., Sydorenko M.V., Makarenko A.N., Kulchikov A.E. Cytoprotective effect of neuropeptides on immunocompetent cells (in vitro research) // Experimental and clinical pharmacology. - 2009. - vol. 79. - p. 28-31.
7. Garmanchuk L.V., Perepelitsyna O.M., Sydorenko M.V., Ostapchenko L.I. Growth kinetics of 2- and 3-D cell models as influenced by microenvironment // Cytology and genetics. - 2009. - No. 5. - R. 305-309.
8. Kulchikov A.E., Molozavaya O.S., Skachkova O.V., Garmanchuk L.V., Sydorenko M.V., Perepelitsyna E.M., Khranovskaya N.N., Makarenko A.N. Comparative study of the immunocorrective action of neuropeptide drugs in acute cerebrovascular pathology // Cytokines and inflammation. - 2009. - No. 3. - Pages 18-23.
9. Garmanchuk L.V., Perepelitsyna O.M., Sydorenko M.V., Ostapchenko L.I. Formation of multicellular aggregates under different conditions of microenvironment // Cytology and genetics. - 2010. - vol. 44, No. 1. - R. 19-22.
10. Perepelitsina O.M., Harmanchuk L.V., Shevchenko E.A., Sydorenko M.V., Ostapchenko L.I. Comparison of the level of NO production and the proliferation of MCF-7 breast cancer cells during modification of the microenvironment // Ukr. biochemical journal. - 2010. - Vol. 82, No. 4. - P. 60-68.
11. Nepiyvoda H.D., Garmanchuk L.V., Perepelitsina O.M., Skachkova O.V., Khranovska N.M., Sydorenko M.V., Ostapchenko L.I. Survival of 3-D culture of MCF-7 cells in a serum-free environment // Reports of the National Academy of Sciences of Ukraine. – 2011. - No. 8. - P. 160-164.
12. Harmanchuk L.V., Khranovskaya N.N., Makarenko A.N., Mazur O.V., Skachkova O.V., Nepiyvoda H.D., Lavrova E.V., Perepelitsyna E.M., Senchylo N.V., Vasilyeva I.G., Ostapchenko L.I. Complex study of the immunomodulating influence of drugs with a nootropic mechanism of action on immunocompetent cells // Journal. National Academy of Sciences of Ukraine. - 2011. - 17, No. 3. - P. 218-226.
11. Perepelitsyna O.M., Garmanchouk L.V., Sydorenko M.V. Indirect influence of co-cultures MT4 on multicellular spheroids of breast adenocarcinoma (MCF7) // UICC, World-cancer congress, 31 August 2008, Geneva, Switzerland. [POS-B146].
12. Perepelitsyna E.M., Harmanchuk L.V., Kobelskaya E.S., Sydorenko M.V. Multidirectional influence of K-environment of tumor lymphocytes on the proliferative activity of MSC-7 cells growing in 2-D and 3-D cultures // New cryobiotechnologies for solving fundamental and applied problems of medicine, November 26-28, 2008, Kharkiv, Ukraine.
13. Harmanchuk L.V. Perepelitsyna E.M., Sydorenko M.V., Makarenko A.N., Kulchikov A.E. Comparative study of the effect of neuroprotectors on T-lymphocytes // Materials of the XVI Russian National Congress "Man and Medicine", April 6-10, 2009, Moscow, Russia.
14. Harmanchuk L.V., Perepelitsyna E.M., Sydorenko M.V., Makarenko A.N., Kulchikov A.E. Comparative study of the action of neuroprotectors on B-lymphocytes // Materials of the XVI Russian National Congress "Man and Medicine", April 6-10, 2009, Moscow, Russia.
15. Harmanchuk L.V., Perepelitsyna E.M., Nepiyvoda K.D., Ostapchenko L.I., Sydorenko M.V. Autocrine production of EGFR-like polypeptides by tumor cells as a factor in their progression //Biologically active substances, fundamental and applied issues of production and use, May 25, 2009, New World, Crimea, Ukraine. - Page 285-286.
16. Perepelitsyna O.M., Shevchenko E.A., Skopenko O.V., Garmanchuk L.V., Aleksieva I.V., Palchikovska L.G., Sidorenko M.V. 6-azacytidine xylofuranoside inhibits the production of nitric oxide by plump cells MCF-7 // Biologically active substances, fundamental and applied issues of production and application, May 25, 2009, New World, Crimea, Ukraine. - Page. 379-380.
17. Yavorskaya N.V., Garmanchuk L.V., Perepelitsyna E.M., Senchilo N.V., Furzikova T.M., Nesterova O.V., Kokozey V.N., Pozur V.K. Bactericidal, fungicidal and cytotoxic effects of heterobimetallic complexes // Biologically active substances, fundamental and applied issues of production and application, May 25, 2009, New World, Crimea, Ukraine. - Page. 451-452.
18. Perepelytsina O.M., Garmanchouk L.V., Sidorenko M.V., Kobelska O.S., Spivak N.J., Makarenko A.N. Immunotherapy and development of the cultural breast cancer // Annals of Oncology. - 2009. - vol. 20, no. 2. – P.85.
19. Garmanchuk L.V., Perepelitsyna E.M., Sidorenko M.V., Makarenko A.N., Kulchikov A.E. Cytoprotective effect of neuropeptides on immunocompetent cells (in vitro study) // Experimental and clinical pharmacology. - 2009. – 79, No. 4. – pp. 28-32.
20. Kobelska O.S., Zholobak N.M., Olenivska Z.M., Perepelitsina O.M., Maltsev G.V., Lyakhov S.A., Andronati S.A., Spivak M.Ya. Investigation of the toxicity and interferonogenic activity of biphenyl-like substances in the culture of MT-4 cells // XII Meeting of the Association of Microbiologists of Ukraine named after S.M. Vinogradsky, grass 2009. - P. 192.
21. Perepelytsina O., Garmanchouk L., Sydorenko M., Ostapchenko L.I. Role of paracrine influence of T-lymphocytes in the regulation of the breast carcinogenesis on model of multicellular tumor spheroids // Breast Cancer Conference, March 2011, St.-Gallen, Switzerland.
22. Perepelytsina O., Garmanchouk L., Sydorenko M., Gergeliuk T. Estrogen abrogated cytotoxic effect of tamoxifen on MCF-7 after activation of estrogen receptor by T-cells // ESMO-IMPAKT conference, May 2011, Brussels, Belgium.
t. Perepelytsina O., Sydorenko M., Skachkova O., Gergeliuk T. Methods for increasing titer of IFN in the body influencing the effectiveness of hormonal therapy of breast cancer // Biologycally active substances: fundamental and applied problems, May 2011, Kiev Ukraine.
23. Garmanchuk L.V., Cheshuk V.E., Perepelitsina E.M., Sydorenko M.V. EGFR exspression and dimerization in the breast cancer resected postoperative tissue can be negative prognostic factor // Primary therapy of early breast cancer/The Breast: 11th internat. conference., 11-14 March 2009.: abstract book.- St. Galen, Switzerlald, 2009. - [0042].-S.28.
“Investigation of the anti-oncogenic activity of biological proteins of the cell gait.” (Term of Vikonanny 2011-2015)
Publications:
1. Indirect influence of co-cultures MT4 on multicellular spheroids of breast adenocarcinoma (MCF7); UICC, World-cancer congress, 31 August, 2008, Geneva [POS-B146]; Perepelitsyna O.M., Garmanchouk L.V., Sydorenko M.V.
2. Reactivity and sensibility of breast adenocarcinoma (MCF-7) in coculture depends on architecture of cells model; Physics of the Alive, v.16, No.2, 2008; Perepelitsyna O.M., Garmanchouk L.V., Sydorenko M.V., Ostapchenko L.I.
3. EGFR expression and dimerization in the breast cancer resected postoperative tissue can be a negative prognostic factor; THE BREAST, Volume 18, Supplement 1, March 2009, P S28; Garmanchouk L.V., O.M.Perepelytsina, V.E. Cheshuk, M.V. Sydorenko.
4. Growth Kinetics of 2- and 3-D Cell Models as Influenced by the Microenvironment; Cytology and genetics, 2009, Vol.43, No.5, P 305-309; L.V. Garmanchouk, O.M. Perepelytsina, M.V. Sidorenko, L.I. Ostapchenko.
5. Formation of Multicellular Aggregates under Different conditions of microenvironment; Cytology and genetics.- 2010.- Vol.44, No. 1.- P. 19-22; Perepelitsyna O.M., Garmanchouk L.V., Sydorenko M.V., Ostapchenko L.I.
6. Role of paracrine influence of T-lymphocytes in the regulation of the breast carcinogenesis on model of multicellular tumor spheroids; St. Gallen Breast Cancer Conference, March, 2011; Abstract, poster presentation; Perepelytsina O., Garmanchouk L., Sydorenko M., Ostapchenko L.I.
7. Estrogen abrogated cytotoxic effect of tamoxifen on MCF-7 after activation of estrogen receptor by T-cells; ESMO-IMPAKT conference, Brussels, May, 2011. Grand Susan G Commen for cure; Abstract, poster presentation; Perepelytsina O., Garmanchouk L., Sydorenko M., Gergeliuk T.
8. Perepelitsyna O. M., Gergelyuk T. S., Demianenko D., Goncharuk O., Golstev A., Sydorenko M. V. The receptor profile of breast tumor cells and formation of spheroids under influence of MSC // In this supplement primary therapy of early breast cancer 13 TH international conference st. Gallen, Switzerland, 13-16 March 2013.
9. Perepelitsyna O. M., Gergelyuk T. S., Demianenko D., Sydorenko M. V. Formation of multicellular tumor spheroids by MCF-7 and sensitivities to anticancer therapy // In this supplement primary therapy of early breast cancer 13-th international conference St. Gallen, Switzerland, March 13-16, 2013.
10. T.S. Gergelyuk, O.M. Perepelitsina, M.V. Sydorenko Comparison of the effects of conditioned medium from human mesenchymal stem cells and interferon-A on the development of the MCF-7 tumor cell population // Bukovynsky medical bulletin. - 2014. - No. 2 (70). - Page 18-23.
11. Demianenko D., Perepelytsina O., Yastrebova O., Sydprenko M. Effect of IFN-alpha and IFN-gamma on proliferation and receptor profile line of breast and colon cancer cells // Collection of scientific papers - International symposium on cell biology jointly with the 4th Ukrainian congress for cell biology. - September 17-20, 2014, Uzhhorod, Ukraine.
"Development of a cellular test system for evaluating the effectiveness and mechanisms of action of anticancer drugs" (Performance term 2016-2020
Publications:
1. Perepelytsina O.M., Yakymchuk O., Vdovichenko N., Sydorenko M.V., Bakalinska O.N. Tumor spheroids as a model for testing new anticancer drugs and not only // Enabling technologies in 3D cancer organoids, March 8-9, 2016, Torino, Italy.
2. Herheliuk T., Perepelytsina O., Ostapchenko L., Yakymchuk O., Sydorenko M. Comparison of biological properties of C-medium from mesenchymal stem cells on 2D and 3D cells cultures of MCF-7 // Collection of theses of the XII International Scientific conference of students and postgraduates "Youth and the progress of biology" - Lviv, April 25-27, 2017, Ukraine. - p. 243.
"Testing of a carbon-protein construct for the targeted delivery of anticancer drugs" of the targeted complex interdisciplinary program of scientific research of the National Academy of Sciences of Ukraine "Molecular and cellular biotechnologies for the needs of medicine, industry and agriculture" and the order of the Presidium of the National Academy of Sciences of Ukraine dated 04.17.15 No. 289. (Execution period 2015 -2019).
Publications:
1. Perepelytsina O.M., Yakymchuk O.M., Sydorenko M.V., Bakalinska O.N., Blosi F., Califano V., Vicari L.R.M. Functionalisation of carbon nanomaterials surface by doxorubicin and antibodies to tumor markers // European Materials Research Society, 2015 Spring meeting, 11-15 May 2015, Lille Grand Palais, France.
2. Perepelytsina O.M., Yakymchuk O.M., Sydorenko M.V., Bakalinska O.N., Blosi F., Califano V., Vicari L.R.M. Impact of functionalized carbon nanomaterials on human tumor cells // III International research and practical conference "Nanochemistry and biotechnology" of International research and practice conference "Nanotechnology and nanomaterials", 26-29.08.2015. Lviv., Ukraine.
3. Perepelytsina O.M., Yakymchuk O.M., Sydorenko M.V., Bakalinska O.N. Functionalization of carbon nanomaterials surface by Doxorubicin and antibodies to tumor markers // Nanoscale Research Letters. - 2016. - 11(1):314. DOI: 10.1186/s11671-016-1537-z.
4. Ugnivenko A.P., Perepelitsina O.M., Sydorenko M.V., Ostapchenko L.I. Carbon nanotubes in delivery of bioactive substances // J. Bionanoscience. - 2017. - Vol. 11, No. 6 (17). - P. 531-547. doi.org/10.1166/jbns.2017.1475
5. Nesterenko O.M., Herheliuk T.S., Perepelytsina O.M., Sydorenko M.V., Bakalinska O.M., Ostapchenko L.I. Investigation of the degree of binding and controlled release of doxorubicin from the UDD and OLC // Proceedings of Ukrainian Conference with Internetional participationn "Chemistry, physics and technology of surface" and Workshop "Nanostructured biocompatible/bioactive material". - P. 112. 24-25 May, 2017. Kyiv, Ukraine.
6. Goncharuk O.V., Ugnivenko A.P., Terpilowski K., Skwarek E., Gun'ko V.M. Effect of ethonium adsorption on structure formation in nanosilica dispersions // // Proceedings of Ukrainian Conference with Internetional participationn "Chemistry, physics and technology of surface" and Workshop "Nanostructured biocompatible/bioactive material". - P. 66. 24-25 May, 2017. Kyiv, Ukraine.
7. Nesterenko O.M., Herheliuk T.S., Perepelytsina O.M., Sydorenko M.V., Bakalinska O.M., Ostapchenko L.I. Investigation of the effectiveness of carbon nanotubes for targeted delivery of antitumor drugs, International research and practice conference: Nanotechnology and Nanomaterials (NANO-2017), August 23-26, 2017, p. 636, Chernivtsi, Ukraine.
Development of a cellular test system for determining the effectiveness and mechanisms of action of anticancer drugs
Determination of the biosafety and cytotoxic effect of gold nanoparticles on monolayer and spheroid culture of tumor cells
Study of the effect of metal-containing and carbon nanomaterials as a matrix on cell growth in vitro
Study of the effect of metal-containing and carbon nanomaterials as a matrix on cell growth in vitro
